SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health
Proper timely management of various external and internal stresses is critical for metabolic and redox homeostasis in mammals. In particular, dysregulation of mechanistic target of rapamycin complex (mTORC) triggered from metabolic stress and accumulation of reactive oxygen species (ROS) generated f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.603421/full |
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| author | Seung-Hyun Ro Julianne Fay Cesar I. Cyuzuzo Yura Jang Yura Jang Naeun Lee Hyun-Seob Song Hyun-Seob Song Edward N. Harris |
| author_facet | Seung-Hyun Ro Julianne Fay Cesar I. Cyuzuzo Yura Jang Yura Jang Naeun Lee Hyun-Seob Song Hyun-Seob Song Edward N. Harris |
| author_sort | Seung-Hyun Ro |
| collection | DOAJ |
| description | Proper timely management of various external and internal stresses is critical for metabolic and redox homeostasis in mammals. In particular, dysregulation of mechanistic target of rapamycin complex (mTORC) triggered from metabolic stress and accumulation of reactive oxygen species (ROS) generated from environmental and genotoxic stress are well-known culprits leading to chronic metabolic disease conditions in humans. Sestrins are one of the metabolic and environmental stress-responsive groups of proteins, which solely have the ability to regulate both mTORC activity and ROS levels in cells, tissues and organs. While Sestrins are originally reported as one of several p53 target genes, recent studies have further delineated the roles of this group of stress-sensing proteins in the regulation of insulin sensitivity, glucose and fat metabolism, and redox-function in metabolic disease and aging. In this review, we discuss recent studies that investigated and manipulated Sestrins-mediated stress signaling pathways in metabolic and environmental health. Sestrins as an emerging dynamic group of stress-sensor proteins are drawing a spotlight as a preventive or therapeutic mechanism in both metabolic stress-associated pathologies and aging processes at the same time. |
| first_indexed | 2024-12-20T01:07:27Z |
| format | Article |
| id | doaj.art-47022f999d9c4e3cb47e6f0a3a3230dd |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-20T01:07:27Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-47022f999d9c4e3cb47e6f0a3a3230dd2022-12-21T19:58:47ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-12-01810.3389/fcell.2020.603421603421SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental HealthSeung-Hyun Ro0Julianne Fay1Cesar I. Cyuzuzo2Yura Jang3Yura Jang4Naeun Lee5Hyun-Seob Song6Hyun-Seob Song7Edward N. Harris8Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, United StatesDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United StatesProper timely management of various external and internal stresses is critical for metabolic and redox homeostasis in mammals. In particular, dysregulation of mechanistic target of rapamycin complex (mTORC) triggered from metabolic stress and accumulation of reactive oxygen species (ROS) generated from environmental and genotoxic stress are well-known culprits leading to chronic metabolic disease conditions in humans. Sestrins are one of the metabolic and environmental stress-responsive groups of proteins, which solely have the ability to regulate both mTORC activity and ROS levels in cells, tissues and organs. While Sestrins are originally reported as one of several p53 target genes, recent studies have further delineated the roles of this group of stress-sensing proteins in the regulation of insulin sensitivity, glucose and fat metabolism, and redox-function in metabolic disease and aging. In this review, we discuss recent studies that investigated and manipulated Sestrins-mediated stress signaling pathways in metabolic and environmental health. Sestrins as an emerging dynamic group of stress-sensor proteins are drawing a spotlight as a preventive or therapeutic mechanism in both metabolic stress-associated pathologies and aging processes at the same time.https://www.frontiersin.org/articles/10.3389/fcell.2020.603421/fullSestrinsenvironmental stressagingmetabolic diseaseobesity/inflammationmTORC |
| spellingShingle | Seung-Hyun Ro Julianne Fay Cesar I. Cyuzuzo Yura Jang Yura Jang Naeun Lee Hyun-Seob Song Hyun-Seob Song Edward N. Harris SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health Frontiers in Cell and Developmental Biology Sestrins environmental stress aging metabolic disease obesity/inflammation mTORC |
| title | SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health |
| title_full | SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health |
| title_fullStr | SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health |
| title_full_unstemmed | SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health |
| title_short | SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health |
| title_sort | sestrins emerging dynamic stress sensors in metabolic and environmental health |
| topic | Sestrins environmental stress aging metabolic disease obesity/inflammation mTORC |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.603421/full |
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