K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins
Abstract Mutation of the Lys-336 residue of actin to Ile (K336I) or Asp (K336E) causes congenital myopathy. To understand the effect of this mutation on the function of actin filaments and gain insight into the mechanism of disease onset, we prepared and biochemically characterised K336I mutant acti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-41795-w |