Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France.
Cytomegalovirus (CMV) is the most frequent cause of congenital infection. The objective of this study was to evaluate predictive factors for CMV seronegativity in a cohort of pregnant women in Paris, France.Pregnant women enrolled in a prospective cohort during the 2009 A/H1N1 pandemic were tested f...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3933677?pdf=render |
| _version_ | 1818196210081595392 |
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| author | Dieynaba S N'Diaye Yazdan Yazdanpanah Anne Krivine Thibaut Andrieu Flore Rozenberg Olivier Picone Vassilis Tsatsaris François Goffinet Odile Launay |
| author_facet | Dieynaba S N'Diaye Yazdan Yazdanpanah Anne Krivine Thibaut Andrieu Flore Rozenberg Olivier Picone Vassilis Tsatsaris François Goffinet Odile Launay |
| author_sort | Dieynaba S N'Diaye |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) is the most frequent cause of congenital infection. The objective of this study was to evaluate predictive factors for CMV seronegativity in a cohort of pregnant women in Paris, France.Pregnant women enrolled in a prospective cohort during the 2009 A/H1N1 pandemic were tested for CMV IgG antibodies. Variables collected were age, geographic origin, lifestyle, work characteristics, socioeconomic status, gravidity, parity and number of children at home. A multivariate logistic regression model was used to identify independent predictive factors for CMV seropositivity.Among the 826 women enrolled, 389 (47.1%) were primiparous, and 552 (67.1%) had Metropolitan France as a geographic origin. Out of these, 355 (i.e. 57.0%, 95% confidence interval (CI): [53.6%-60.4%]) were CMV seropositive: 43.7% (95% CI:[39.5%-47.9%]) in those whose geographic origin was Metropolitan France and 84.1% in those with other origins (95% CI:[79.2%-88.3%]). Determinants associated with CMV seropositivity in a multivariate logistic regression model were: (i) geographic origin (p<0.001(compared with Metropolitan France, geographic origins of Africa adjusted odds ratio (aOR) 21.2, 95% CI:[9.7-46.5], French overseas departments and territories and other origin, aOR 7.5, 95% CI:[3.9-14.6], and Europe or Asia, aOR 2.2, 95% CI: [1.3-3.7]); and (ii) gravidity (p = 0.019), (compared with gravidity = 1, if gravidity≥3, aOR = 1.5, 95% CI: [1.1-2.2]; if gravidity = 2, aOR = 1.0, 95% CI: [0.7-1.4]). Work characteristics and socioeconomic status were not independently associated with CMV seropositivity.In this cohort of pregnant women, a geographic origin of Metropolitan France and a low gravidity were predictive factors for CMV low seropositivity. Such women are therefore the likely target population for prevention of CMV infection during pregnancy in France. |
| first_indexed | 2024-12-12T01:30:27Z |
| format | Article |
| id | doaj.art-470624846cd147f8a160f8a9b63b5807 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T01:30:27Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-470624846cd147f8a160f8a9b63b58072022-12-22T00:43:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8985710.1371/journal.pone.0089857Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France.Dieynaba S N'DiayeYazdan YazdanpanahAnne KrivineThibaut AndrieuFlore RozenbergOlivier PiconeVassilis TsatsarisFrançois GoffinetOdile LaunayCytomegalovirus (CMV) is the most frequent cause of congenital infection. The objective of this study was to evaluate predictive factors for CMV seronegativity in a cohort of pregnant women in Paris, France.Pregnant women enrolled in a prospective cohort during the 2009 A/H1N1 pandemic were tested for CMV IgG antibodies. Variables collected were age, geographic origin, lifestyle, work characteristics, socioeconomic status, gravidity, parity and number of children at home. A multivariate logistic regression model was used to identify independent predictive factors for CMV seropositivity.Among the 826 women enrolled, 389 (47.1%) were primiparous, and 552 (67.1%) had Metropolitan France as a geographic origin. Out of these, 355 (i.e. 57.0%, 95% confidence interval (CI): [53.6%-60.4%]) were CMV seropositive: 43.7% (95% CI:[39.5%-47.9%]) in those whose geographic origin was Metropolitan France and 84.1% in those with other origins (95% CI:[79.2%-88.3%]). Determinants associated with CMV seropositivity in a multivariate logistic regression model were: (i) geographic origin (p<0.001(compared with Metropolitan France, geographic origins of Africa adjusted odds ratio (aOR) 21.2, 95% CI:[9.7-46.5], French overseas departments and territories and other origin, aOR 7.5, 95% CI:[3.9-14.6], and Europe or Asia, aOR 2.2, 95% CI: [1.3-3.7]); and (ii) gravidity (p = 0.019), (compared with gravidity = 1, if gravidity≥3, aOR = 1.5, 95% CI: [1.1-2.2]; if gravidity = 2, aOR = 1.0, 95% CI: [0.7-1.4]). Work characteristics and socioeconomic status were not independently associated with CMV seropositivity.In this cohort of pregnant women, a geographic origin of Metropolitan France and a low gravidity were predictive factors for CMV low seropositivity. Such women are therefore the likely target population for prevention of CMV infection during pregnancy in France.http://europepmc.org/articles/PMC3933677?pdf=render |
| spellingShingle | Dieynaba S N'Diaye Yazdan Yazdanpanah Anne Krivine Thibaut Andrieu Flore Rozenberg Olivier Picone Vassilis Tsatsaris François Goffinet Odile Launay Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. PLoS ONE |
| title | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_full | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_fullStr | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_full_unstemmed | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_short | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_sort | predictive factors of cytomegalovirus seropositivity among pregnant women in paris france |
| url | http://europepmc.org/articles/PMC3933677?pdf=render |
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