Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period
This cohort study examined 25-year variations in cancer incidence among 11,418 Italian recipients of kidney transplantation (KT) from 17 Italian centers. Cancer incidence was examined over three periods (1997–2004; 2005–2012; and 2013–2021) by internal (Incidence rate ratio-IRR) and external (standa...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/4/1347 |
| _version_ | 1797621846799024128 |
|---|---|
| author | Pierluca Piselli Diego Serraino Claudia Cimaglia Lucrezia Furian Luigi Biancone Ghil Busnach Nicola Bossini Paola Todeschini Maurizio Iaria Franco Citterio Mariarosaria Campise Massimiliano Veroux Giuseppe Tisone Vincenzo Cantaluppi Margherita Mangino Simona Simone Davide Argiolas Andrea Ambrosini Francesco Pisani Flavia Caputo Martina Taborelli |
| author_facet | Pierluca Piselli Diego Serraino Claudia Cimaglia Lucrezia Furian Luigi Biancone Ghil Busnach Nicola Bossini Paola Todeschini Maurizio Iaria Franco Citterio Mariarosaria Campise Massimiliano Veroux Giuseppe Tisone Vincenzo Cantaluppi Margherita Mangino Simona Simone Davide Argiolas Andrea Ambrosini Francesco Pisani Flavia Caputo Martina Taborelli |
| author_sort | Pierluca Piselli |
| collection | DOAJ |
| description | This cohort study examined 25-year variations in cancer incidence among 11,418 Italian recipients of kidney transplantation (KT) from 17 Italian centers. Cancer incidence was examined over three periods (1997–2004; 2005–2012; and 2013–2021) by internal (Incidence rate ratio-IRR) and external (standardized incidence ratios-SIR) comparisons. Poisson regression was used to assess trends. Overall, 1646 post-transplant cancers were diagnosed, with incidence rates/1000 person-years ranging from 15.5 in 1997–2004 to 21.0 in 2013–2021. Adjusted IRRs showed a significant reduction in incidence rates across periods for all cancers combined after exclusion of nonmelanoma skin cancers (IRR = 0.90, 95% confidence interval-CI: 0.76–1.07 in 2005–2012; IRR = 0.72, 95% CI: 0.60–0.87 in 2013–2021 vs. 1997–2004; P<sub>trend</sub> < 0.01). In site-specific analyses, however, significant changes in incidence rates were observed only for Kaposi’s sarcoma (KS; IRR = 0.37, 95% CI: 0.24–0.57 in 2005–2012; IRR = 0.09, 95% CI: 0.04–0.18 in 2013–2021; P<sub>trend</sub> < 0.01). As compared to the general population, the overall post-transplant cancer risk in KT recipients was elevated, with a decreasing magnitude over time (SIR = 2.54, 95% CI: 2.26–2.85 in 1997–2004; SIR = 1.99, 95% CI: 1.83–2.16 in 2013–2021; P<sub>trend</sub> < 0.01). A decline in SIRs was observed specifically for non-Hodgkin lymphoma and KS, though only the KS trend retained statistical significance after adjustment. In conclusion, apart from KS, no changes in the incidence of other cancers over time were observed among Italian KT recipients. |
| first_indexed | 2024-03-11T09:01:48Z |
| format | Article |
| id | doaj.art-4706ca5853174fa28e147a03fb342939 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:01:48Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4706ca5853174fa28e147a03fb3429392023-11-16T19:39:44ZengMDPI AGCancers2072-66942023-02-01154134710.3390/cancers15041347Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year PeriodPierluca Piselli0Diego Serraino1Claudia Cimaglia2Lucrezia Furian3Luigi Biancone4Ghil Busnach5Nicola Bossini6Paola Todeschini7Maurizio Iaria8Franco Citterio9Mariarosaria Campise10Massimiliano Veroux11Giuseppe Tisone12Vincenzo Cantaluppi13Margherita Mangino14Simona Simone15Davide Argiolas16Andrea Ambrosini17Francesco Pisani18Flavia Caputo19Martina Taborelli20Department of Epidemiology and Pre-Clinical Research, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, ItalyUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, ItalyDepartment of Epidemiology and Pre-Clinical Research, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, ItalyUnit of Kidney and Pancreas Transplantation, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, 35128 Padova, ItalyDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center “A. Vercellone”, Città della Salute e della Scienza University Hospital, 10126 Turin, ItalyGrande Ospedale Metropolitano Niguarda, 20162 Milano, ItalyUnit of Nephrology, ASST Spedali Civili di Brescia, 25123 Brescia, ItalyDepartment of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, IRCCS S. Orsola Hospital, University of Bologna, 40138 Bologna, ItalyDepartment of General and Specialized Surgery, Division of General Surgery, Transplant Surgery Unit, Parma University Hospital, 43126 Parma, ItalyDepartment of Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyUnit of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milano, ItalyOrgan Transplantation Unit, Department of Medical and Surgical Sciences and Advanced Technologies, University Hospital of Catania, 95123 Catania, ItalyUOC Transplant Unit, Department of Surgery, Tor Vergata University, 00133 Rome, ItalyNephrology and Kidney Transplantation Unit, Department of Translational Medicine, University of Piemonte Orientale (UPO), “Maggiore della Carità” University Hospital, 28100 Novara, ItalyNephrology, Dialysis, Transplantation Unit, Ca’ Foncello Hospital, 31100 Treviso, ItalyNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyRenal Transplant Unit, Azienda Ospedaliera Brotzu, 09047 Cagliari, ItalyRenal Transplant Unit, Azienda Ospedaliera Ospedale di Circolo e Fondazione Macchi, 21100 Varese, ItalyGeneral and Transplant Surgery Department, University of L’Aquila, 67100 L’Aquila, ItalyNephrology Dialysis and Renal Transplant Department, Civico and Di Cristina Hospital, 90127 Palermo, ItalyUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, ItalyThis cohort study examined 25-year variations in cancer incidence among 11,418 Italian recipients of kidney transplantation (KT) from 17 Italian centers. Cancer incidence was examined over three periods (1997–2004; 2005–2012; and 2013–2021) by internal (Incidence rate ratio-IRR) and external (standardized incidence ratios-SIR) comparisons. Poisson regression was used to assess trends. Overall, 1646 post-transplant cancers were diagnosed, with incidence rates/1000 person-years ranging from 15.5 in 1997–2004 to 21.0 in 2013–2021. Adjusted IRRs showed a significant reduction in incidence rates across periods for all cancers combined after exclusion of nonmelanoma skin cancers (IRR = 0.90, 95% confidence interval-CI: 0.76–1.07 in 2005–2012; IRR = 0.72, 95% CI: 0.60–0.87 in 2013–2021 vs. 1997–2004; P<sub>trend</sub> < 0.01). In site-specific analyses, however, significant changes in incidence rates were observed only for Kaposi’s sarcoma (KS; IRR = 0.37, 95% CI: 0.24–0.57 in 2005–2012; IRR = 0.09, 95% CI: 0.04–0.18 in 2013–2021; P<sub>trend</sub> < 0.01). As compared to the general population, the overall post-transplant cancer risk in KT recipients was elevated, with a decreasing magnitude over time (SIR = 2.54, 95% CI: 2.26–2.85 in 1997–2004; SIR = 1.99, 95% CI: 1.83–2.16 in 2013–2021; P<sub>trend</sub> < 0.01). A decline in SIRs was observed specifically for non-Hodgkin lymphoma and KS, though only the KS trend retained statistical significance after adjustment. In conclusion, apart from KS, no changes in the incidence of other cancers over time were observed among Italian KT recipients.https://www.mdpi.com/2072-6694/15/4/1347kidney transplantimmunosuppressionvirus-related malignancytrendItalycohort study |
| spellingShingle | Pierluca Piselli Diego Serraino Claudia Cimaglia Lucrezia Furian Luigi Biancone Ghil Busnach Nicola Bossini Paola Todeschini Maurizio Iaria Franco Citterio Mariarosaria Campise Massimiliano Veroux Giuseppe Tisone Vincenzo Cantaluppi Margherita Mangino Simona Simone Davide Argiolas Andrea Ambrosini Francesco Pisani Flavia Caputo Martina Taborelli Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period Cancers kidney transplant immunosuppression virus-related malignancy trend Italy cohort study |
| title | Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period |
| title_full | Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period |
| title_fullStr | Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period |
| title_full_unstemmed | Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period |
| title_short | Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period |
| title_sort | variation in post transplant cancer incidence among italian kidney transplant recipients over a 25 year period |
| topic | kidney transplant immunosuppression virus-related malignancy trend Italy cohort study |
| url | https://www.mdpi.com/2072-6694/15/4/1347 |
| work_keys_str_mv | AT pierlucapiselli variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT diegoserraino variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT claudiacimaglia variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT lucreziafurian variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT luigibiancone variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT ghilbusnach variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT nicolabossini variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT paolatodeschini variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT maurizioiaria variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT francocitterio variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT mariarosariacampise variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT massimilianoveroux variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT giuseppetisone variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT vincenzocantaluppi variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT margheritamangino variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT simonasimone variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT davideargiolas variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT andreaambrosini variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT francescopisani variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT flaviacaputo variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod AT martinataborelli variationinposttransplantcancerincidenceamongitaliankidneytransplantrecipientsovera25yearperiod |