Targeting Glutaminolysis Shows Efficacy in Both Prednisolone-Sensitive and in Metabolically Rewired Prednisolone-Resistant B-Cell Childhood Acute Lymphoblastic Leukaemia Cells

Targeting Glutaminolysis Shows Efficacy in Both Prednisolone-Sensitive and in Metabolically Rewired Prednisolone-Resistant B-Cell Childhood Acute Lymphoblastic Leukaemia Cells

The prognosis for patients with relapsed childhood acute lymphoblastic leukaemia (cALL) remains poor. The main reason for treatment failure is drug resistance, most commonly to glucocorticoids (GCs). The molecular differences between prednisolone-sensitive and -resistant lymphoblasts are not well-st...

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Bibliographic Details
Main Authors: Yordan Sbirkov, Bozhidar Vergov, Vasil Dzharov, Tino Schenk, Kevin Petrie, Victoria Sarafian
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
childhood ALL
metabolism
metabolomics
glutaminolysis
glutamine
EGCG (epigallocatechin gallate)
Online Access:https://www.mdpi.com/1422-0067/24/4/3378

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