Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literature
Uterine leiomyosarcoma (uLMS) is a rare and aggressive cancer, usually diagnosed incidentally at the time of myomectomy or hysterectomy. There have been concerns for several years about the fact that the inadvertent disruption of occult uLMS may have a negative impact on patient outcome. This study...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Gynecology and Minimally Invasive Therapy |
| Subjects: | |
| Online Access: | http://www.e-gmit.com/article.asp?issn=2213-3070;year=2018;volume=7;issue=2;spage=47;epage=55;aulast=Tantitamit |
| _version_ | 1811245350579601408 |
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| author | Tanitra Tantitamit Kuan-Gen Huang Manatsawee Manopunya Chih-Feng Yen |
| author_facet | Tanitra Tantitamit Kuan-Gen Huang Manatsawee Manopunya Chih-Feng Yen |
| author_sort | Tanitra Tantitamit |
| collection | DOAJ |
| description | Uterine leiomyosarcoma (uLMS) is a rare and aggressive cancer, usually diagnosed incidentally at the time of myomectomy or hysterectomy. There have been concerns for several years about the fact that the inadvertent disruption of occult uLMS may have a negative impact on patient outcome. This study reviews the outcome and management of patients with a diagnosis of uLMS after surgery for presumed benign disease. We conducted a literature search in which 47 published English-language articles were obtained for evaluation. A total of 23 studies with outcomes data were included. It is evidenced that patients who underwent surgery with tumor disruption resulted in poorer outcomes compared with en bloc tumor, especially by power morcellation. The power morcellation was associated with an increased risk of recurrence, shorten time to recurrence, and upstage after re-exploration. Early re-exploration and surgical staging are appreciated for better prognosis and may alter postoperative treatment. We also updated on the incidence and preoperative evaluation to assess the risk of patient and give an effective counseling. |
| first_indexed | 2024-04-12T14:38:00Z |
| format | Article |
| id | doaj.art-470ba09be22a482f9cc0e74d801db7fe |
| institution | Directory Open Access Journal |
| issn | 2213-3070 |
| language | English |
| last_indexed | 2024-04-12T14:38:00Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Gynecology and Minimally Invasive Therapy |
| spelling | doaj.art-470ba09be22a482f9cc0e74d801db7fe2022-12-22T03:28:59ZengWolters Kluwer Medknow PublicationsGynecology and Minimally Invasive Therapy2213-30702018-01-0172475510.4103/GMIT.GMIT_10_18Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literatureTanitra TantitamitKuan-Gen HuangManatsawee ManopunyaChih-Feng YenUterine leiomyosarcoma (uLMS) is a rare and aggressive cancer, usually diagnosed incidentally at the time of myomectomy or hysterectomy. There have been concerns for several years about the fact that the inadvertent disruption of occult uLMS may have a negative impact on patient outcome. This study reviews the outcome and management of patients with a diagnosis of uLMS after surgery for presumed benign disease. We conducted a literature search in which 47 published English-language articles were obtained for evaluation. A total of 23 studies with outcomes data were included. It is evidenced that patients who underwent surgery with tumor disruption resulted in poorer outcomes compared with en bloc tumor, especially by power morcellation. The power morcellation was associated with an increased risk of recurrence, shorten time to recurrence, and upstage after re-exploration. Early re-exploration and surgical staging are appreciated for better prognosis and may alter postoperative treatment. We also updated on the incidence and preoperative evaluation to assess the risk of patient and give an effective counseling.http://www.e-gmit.com/article.asp?issn=2213-3070;year=2018;volume=7;issue=2;spage=47;epage=55;aulast=TantitamitHysterectomymyomectomyoccult leiomyosarcomaprognosis |
| spellingShingle | Tanitra Tantitamit Kuan-Gen Huang Manatsawee Manopunya Chih-Feng Yen Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literature Gynecology and Minimally Invasive Therapy Hysterectomy myomectomy occult leiomyosarcoma prognosis |
| title | Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literature |
| title_full | Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literature |
| title_fullStr | Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literature |
| title_full_unstemmed | Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literature |
| title_short | Outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease: Review of literature |
| title_sort | outcome and management of uterine leiomyosarcoma treated following surgery for presumed benign disease review of literature |
| topic | Hysterectomy myomectomy occult leiomyosarcoma prognosis |
| url | http://www.e-gmit.com/article.asp?issn=2213-3070;year=2018;volume=7;issue=2;spage=47;epage=55;aulast=Tantitamit |
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