Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation

Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phyl...

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Main Authors: C. Sharma, N. Kumar, R. Pandey, J.F. Meis, A. Chowdhary
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:New Microbes and New Infections
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2052297516300749
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author C. Sharma
N. Kumar
R. Pandey
J.F. Meis
A. Chowdhary
author_facet C. Sharma
N. Kumar
R. Pandey
J.F. Meis
A. Chowdhary
author_sort C. Sharma
collection DOAJ
description Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).
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spelling doaj.art-470def9b20934ae8b79a71f66e6dbbaf2022-12-21T18:39:58ZengElsevierNew Microbes and New Infections2052-29752016-09-0113C778210.1016/j.nmni.2016.07.003Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variationC. Sharma0N. Kumar1R. Pandey2J.F. Meis3A. Chowdhary4Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, IndiaWellcome Trust Sanger Institute, Hinxton, UKCSIR Ayurgenomics Unit-TRISUTRA, Council of Scientific & Industrial Research–Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, IndiaDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The NetherlandsDepartment of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, IndiaCandida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).http://www.sciencedirect.com/science/article/pii/S2052297516300749Candida aurisIndiamultidrug resistantoutbreakwhole genome sequencing
spellingShingle C. Sharma
N. Kumar
R. Pandey
J.F. Meis
A. Chowdhary
Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
New Microbes and New Infections
Candida auris
India
multidrug resistant
outbreak
whole genome sequencing
title Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_full Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_fullStr Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_full_unstemmed Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_short Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
title_sort whole genome sequencing of emerging multidrug resistant candida auris isolates in india demonstrates low genetic variation
topic Candida auris
India
multidrug resistant
outbreak
whole genome sequencing
url http://www.sciencedirect.com/science/article/pii/S2052297516300749
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