Wnt Signaling Is Required for Long-Term Memory Formation
Wnt signaling regulates synaptic plasticity and neurogenesis in the adult nervous system, suggesting a potential role in behavioral processes. Here, we probed the requirement for Wnt signaling during olfactory memory formation in Drosophila using an inducible RNAi approach. Interfering with β-cateni...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-09-01
|
| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713004312 |
| _version_ | 1818119297620246528 |
|---|---|
| author | Ying Tan Dinghui Yu Germain U. Busto Curtis Wilson Ronald L. Davis |
| author_facet | Ying Tan Dinghui Yu Germain U. Busto Curtis Wilson Ronald L. Davis |
| author_sort | Ying Tan |
| collection | DOAJ |
| description | Wnt signaling regulates synaptic plasticity and neurogenesis in the adult nervous system, suggesting a potential role in behavioral processes. Here, we probed the requirement for Wnt signaling during olfactory memory formation in Drosophila using an inducible RNAi approach. Interfering with β-catenin expression in adult mushroom body neurons specifically impaired long-term memory (LTM) without altering short-term memory. The impairment was reversible, being rescued by expression of a wild-type β-catenin transgene, and correlated with disruption of a cellular LTM trace. Inhibition of wingless, a Wnt ligand, and arrow, a Wnt coreceptor, also impaired LTM. Wingless expression in wild-type flies was transiently elevated in the brain after LTM conditioning. Thus, inhibiting three key components of the Wnt signaling pathway in adult mushroom bodies impairs LTM, indicating that this pathway mechanistically underlies this specific form of memory. |
| first_indexed | 2024-12-11T05:07:58Z |
| format | Article |
| id | doaj.art-470eee6b449b48edbac89bf1915cc17e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T05:07:58Z |
| publishDate | 2013-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-470eee6b449b48edbac89bf1915cc17e2022-12-22T01:19:59ZengElsevierCell Reports2211-12472013-09-01461082108910.1016/j.celrep.2013.08.007Wnt Signaling Is Required for Long-Term Memory FormationYing Tan0Dinghui Yu1Germain U. Busto2Curtis Wilson3Ronald L. Davis4Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458, USADepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USAWnt signaling regulates synaptic plasticity and neurogenesis in the adult nervous system, suggesting a potential role in behavioral processes. Here, we probed the requirement for Wnt signaling during olfactory memory formation in Drosophila using an inducible RNAi approach. Interfering with β-catenin expression in adult mushroom body neurons specifically impaired long-term memory (LTM) without altering short-term memory. The impairment was reversible, being rescued by expression of a wild-type β-catenin transgene, and correlated with disruption of a cellular LTM trace. Inhibition of wingless, a Wnt ligand, and arrow, a Wnt coreceptor, also impaired LTM. Wingless expression in wild-type flies was transiently elevated in the brain after LTM conditioning. Thus, inhibiting three key components of the Wnt signaling pathway in adult mushroom bodies impairs LTM, indicating that this pathway mechanistically underlies this specific form of memory.http://www.sciencedirect.com/science/article/pii/S2211124713004312 |
| spellingShingle | Ying Tan Dinghui Yu Germain U. Busto Curtis Wilson Ronald L. Davis Wnt Signaling Is Required for Long-Term Memory Formation Cell Reports |
| title | Wnt Signaling Is Required for Long-Term Memory Formation |
| title_full | Wnt Signaling Is Required for Long-Term Memory Formation |
| title_fullStr | Wnt Signaling Is Required for Long-Term Memory Formation |
| title_full_unstemmed | Wnt Signaling Is Required for Long-Term Memory Formation |
| title_short | Wnt Signaling Is Required for Long-Term Memory Formation |
| title_sort | wnt signaling is required for long term memory formation |
| url | http://www.sciencedirect.com/science/article/pii/S2211124713004312 |
| work_keys_str_mv | AT yingtan wntsignalingisrequiredforlongtermmemoryformation AT dinghuiyu wntsignalingisrequiredforlongtermmemoryformation AT germainubusto wntsignalingisrequiredforlongtermmemoryformation AT curtiswilson wntsignalingisrequiredforlongtermmemoryformation AT ronaldldavis wntsignalingisrequiredforlongtermmemoryformation |