Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort study
Abstract Background IDegLira is a fixed-ratio combination of insulin degludec and liraglutide with proven efficacy against simpler regimens and non-inferiority against basal-bolus insulin therapy. However, the evaluation of its real-world effectiveness is hindered by technical issues and requires fu...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-022-01139-8 |
| _version_ | 1828376803200204800 |
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| author | Sándor Szépkúti Szilvia Bandur Gábor Kovács Tamás Ferenci Márk M. Svébis Piroska Turbucz Ádám G. Tabák |
| author_facet | Sándor Szépkúti Szilvia Bandur Gábor Kovács Tamás Ferenci Márk M. Svébis Piroska Turbucz Ádám G. Tabák |
| author_sort | Sándor Szépkúti |
| collection | DOAJ |
| description | Abstract Background IDegLira is a fixed-ratio combination of insulin degludec and liraglutide with proven efficacy against simpler regimens and non-inferiority against basal-bolus insulin therapy. However, the evaluation of its real-world effectiveness is hindered by technical issues and requires further exploration. Thus we aimed to compare effectiveness of insulin degludec/liraglutide (IDegLira) versus intensified conventional insulin therapy (ICT) for type 2 diabetes in a real-world setting. Methods This retrospective cohort study from an outpatient clinic in Hungary included people who initiated IDegLira due to inadequate glycaemic control (HbA1c > 7.0% [53.0 mmol/mol]) with oral and/or injectable antidiabetic drugs. Data were compared with a historical cohort who initiated ICT. Outcomes included HbA1c, body weight, and hypoglycaemia differences over 18 months of follow-up. Results Data were included from 227 and 72 people who initiated IDegLira and ICT, respectively. Estimated mean difference (MD) in HbA1c at 18 months favoured IDegLira versus ICT (MD 0.60, 95% CI 0.88–0.32 [MD 6.6 mmol/mol, 95% CI 9.6–3.5]). More people reached target HbA1c ≤7.0% (53.0 mmol/mol) with IDegLira than ICT (odds ratio 3.36, 95% CI 1.52–7.42). IDegLira treatment was associated with weight loss compared with gain for ICT (MD 6.7 kg, 95% CI 5.0–8.5). The hazard ratio for hypoglycaemia comparing IDegLira with ICT was 0.18 (95% CI 0.08–0.49). Conclusions Treatment with IDegLira over 18 months resulted in greater HbA1c reductions, weight loss versus gain, and a lower rate of hypoglycaemia versus ICT in people with type 2 diabetes. |
| first_indexed | 2024-04-14T08:05:10Z |
| format | Article |
| id | doaj.art-470fdc72cac34a62afc8e5b96b99040e |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-14T08:05:10Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-470fdc72cac34a62afc8e5b96b99040e2022-12-22T02:04:47ZengBMCBMC Endocrine Disorders1472-68232022-09-0122111110.1186/s12902-022-01139-8Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort studySándor Szépkúti0Szilvia Bandur1Gábor Kovács2Tamás Ferenci3Márk M. Svébis4Piroska Turbucz5Ádám G. Tabák6Diabetology, Pest County Flór Ferenc HospitalDiabetology, Pest County Flór Ferenc HospitalDiabetology, Pest County Flór Ferenc HospitalPhysiological Controls Research Center, Óbuda UniversityDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineDiabetology, Pest County Flór Ferenc HospitalDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineAbstract Background IDegLira is a fixed-ratio combination of insulin degludec and liraglutide with proven efficacy against simpler regimens and non-inferiority against basal-bolus insulin therapy. However, the evaluation of its real-world effectiveness is hindered by technical issues and requires further exploration. Thus we aimed to compare effectiveness of insulin degludec/liraglutide (IDegLira) versus intensified conventional insulin therapy (ICT) for type 2 diabetes in a real-world setting. Methods This retrospective cohort study from an outpatient clinic in Hungary included people who initiated IDegLira due to inadequate glycaemic control (HbA1c > 7.0% [53.0 mmol/mol]) with oral and/or injectable antidiabetic drugs. Data were compared with a historical cohort who initiated ICT. Outcomes included HbA1c, body weight, and hypoglycaemia differences over 18 months of follow-up. Results Data were included from 227 and 72 people who initiated IDegLira and ICT, respectively. Estimated mean difference (MD) in HbA1c at 18 months favoured IDegLira versus ICT (MD 0.60, 95% CI 0.88–0.32 [MD 6.6 mmol/mol, 95% CI 9.6–3.5]). More people reached target HbA1c ≤7.0% (53.0 mmol/mol) with IDegLira than ICT (odds ratio 3.36, 95% CI 1.52–7.42). IDegLira treatment was associated with weight loss compared with gain for ICT (MD 6.7 kg, 95% CI 5.0–8.5). The hazard ratio for hypoglycaemia comparing IDegLira with ICT was 0.18 (95% CI 0.08–0.49). Conclusions Treatment with IDegLira over 18 months resulted in greater HbA1c reductions, weight loss versus gain, and a lower rate of hypoglycaemia versus ICT in people with type 2 diabetes.https://doi.org/10.1186/s12902-022-01139-8Insulin therapy; liraglutide; type 2 diabetes mellitusGLP-1 agonistsBasal insulinsCohort study |
| spellingShingle | Sándor Szépkúti Szilvia Bandur Gábor Kovács Tamás Ferenci Márk M. Svébis Piroska Turbucz Ádám G. Tabák Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort study BMC Endocrine Disorders Insulin therapy; liraglutide; type 2 diabetes mellitus GLP-1 agonists Basal insulins Cohort study |
| title | Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort study |
| title_full | Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort study |
| title_fullStr | Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort study |
| title_full_unstemmed | Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort study |
| title_short | Real-world effectiveness of IDegLira compared with intensified conventional insulin therapy in adults with type 2 diabetes: a retrospective cohort study |
| title_sort | real world effectiveness of ideglira compared with intensified conventional insulin therapy in adults with type 2 diabetes a retrospective cohort study |
| topic | Insulin therapy; liraglutide; type 2 diabetes mellitus GLP-1 agonists Basal insulins Cohort study |
| url | https://doi.org/10.1186/s12902-022-01139-8 |
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