Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
Abstract Here, we present two patients with bronchial asthma, who developed keratosis pilaris (KP) following treatment with dupilumab, a monoclonal antibody to IL‐4 receptor. Both of them reported pruritic papules in their extremities in 1 months after initiation of dupilumab therapy. The lesions ne...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cia2.12172 |
| _version_ | 1797332332302041088 |
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| author | Yuka Shibata Shigetoshi Sano |
| author_facet | Yuka Shibata Shigetoshi Sano |
| author_sort | Yuka Shibata |
| collection | DOAJ |
| description | Abstract Here, we present two patients with bronchial asthma, who developed keratosis pilaris (KP) following treatment with dupilumab, a monoclonal antibody to IL‐4 receptor. Both of them reported pruritic papules in their extremities in 1 months after initiation of dupilumab therapy. The lesions newly developed on the day of every administration of dupilumab at 2‐week interval, however, they tended to resolve over time until the next treatment. A diagnosis of KP was made from clinical and histopathologic findings. Dermoscopic examination revealed keratotic plugs with coiled, curly hairs. We suspected that dupilumab might abruptly impact on growth of vellus hair to generate KP. |
| first_indexed | 2024-03-08T07:48:44Z |
| format | Article |
| id | doaj.art-4710040ae2894f3f9200982a22409a58 |
| institution | Directory Open Access Journal |
| issn | 2574-4593 |
| language | English |
| last_indexed | 2024-03-08T07:48:44Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj.art-4710040ae2894f3f9200982a22409a582024-02-02T15:14:27ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932021-08-0144828510.1002/cia2.12172Keratosis pilaris caused by dupilumab for the treatment of bronchial asthmaYuka Shibata0Shigetoshi Sano1Department of Dermatology Kochi Medical School Kochi University Nankoku JapanDepartment of Dermatology Kochi Medical School Kochi University Nankoku JapanAbstract Here, we present two patients with bronchial asthma, who developed keratosis pilaris (KP) following treatment with dupilumab, a monoclonal antibody to IL‐4 receptor. Both of them reported pruritic papules in their extremities in 1 months after initiation of dupilumab therapy. The lesions newly developed on the day of every administration of dupilumab at 2‐week interval, however, they tended to resolve over time until the next treatment. A diagnosis of KP was made from clinical and histopathologic findings. Dermoscopic examination revealed keratotic plugs with coiled, curly hairs. We suspected that dupilumab might abruptly impact on growth of vellus hair to generate KP.https://doi.org/10.1002/cia2.12172bronchial asthmacurly hairdupilumabhair folliclekeratosis pilarisTh2 pathway |
| spellingShingle | Yuka Shibata Shigetoshi Sano Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma Journal of Cutaneous Immunology and Allergy bronchial asthma curly hair dupilumab hair follicle keratosis pilaris Th2 pathway |
| title | Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma |
| title_full | Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma |
| title_fullStr | Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma |
| title_full_unstemmed | Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma |
| title_short | Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma |
| title_sort | keratosis pilaris caused by dupilumab for the treatment of bronchial asthma |
| topic | bronchial asthma curly hair dupilumab hair follicle keratosis pilaris Th2 pathway |
| url | https://doi.org/10.1002/cia2.12172 |
| work_keys_str_mv | AT yukashibata keratosispilariscausedbydupilumabforthetreatmentofbronchialasthma AT shigetoshisano keratosispilariscausedbydupilumabforthetreatmentofbronchialasthma |