Regulated cell death in glioma: promising targets for natural small-molecule compounds
Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is less than one year. The main mechanism of regulat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1273841/full |
| _version_ | 1797351420621488128 |
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| author | Mingyu Han Sui Li Huali Fan Junsha An Cheng Peng Fu Peng Fu Peng |
| author_facet | Mingyu Han Sui Li Huali Fan Junsha An Cheng Peng Fu Peng Fu Peng |
| author_sort | Mingyu Han |
| collection | DOAJ |
| description | Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is less than one year. The main mechanism of regulated cell death involves organisms coordinating the elimination of damaged cells at risk of tumor transformation or cells hijacked by microorganisms for pathogen replication. This process includes apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, necrosis, parthanayosis, entosis, lysosome-dependent death, NETosis, oxiptosis, alkaliptosis, and disulfidaptosis. The main goal of clinical oncology is to develop therapies that promote the effective elimination of cancer cells by regulating cell death are the main goal of clinical oncology. Recently, scientists have utilized pertinent regulatory factors and natural small-molecule compounds to induce regulated cell death for the treatment of gliomas. By analyzing the PubMed and Web of Science databases, this paper reviews the research progress on the regulation of cell death and the role of natural small-molecule compounds in glioma. The aim is to provide help for the treatment of glioblastoma. |
| first_indexed | 2024-03-08T13:00:11Z |
| format | Article |
| id | doaj.art-4710d2c221c1409489ffd9f7fbaba6ec |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T13:00:11Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4710d2c221c1409489ffd9f7fbaba6ec2024-01-19T08:31:40ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011410.3389/fonc.2024.12738411273841Regulated cell death in glioma: promising targets for natural small-molecule compoundsMingyu Han0Sui Li1Huali Fan2Junsha An3Cheng Peng4Fu Peng5Fu Peng6West China School of Pharmacy, Sichuan University, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan University, Chengdu, ChinaGliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is less than one year. The main mechanism of regulated cell death involves organisms coordinating the elimination of damaged cells at risk of tumor transformation or cells hijacked by microorganisms for pathogen replication. This process includes apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, necrosis, parthanayosis, entosis, lysosome-dependent death, NETosis, oxiptosis, alkaliptosis, and disulfidaptosis. The main goal of clinical oncology is to develop therapies that promote the effective elimination of cancer cells by regulating cell death are the main goal of clinical oncology. Recently, scientists have utilized pertinent regulatory factors and natural small-molecule compounds to induce regulated cell death for the treatment of gliomas. By analyzing the PubMed and Web of Science databases, this paper reviews the research progress on the regulation of cell death and the role of natural small-molecule compounds in glioma. The aim is to provide help for the treatment of glioblastoma.https://www.frontiersin.org/articles/10.3389/fonc.2024.1273841/fullregulated cell deathgliomanatural small-molecule compoundsregulatory factorspathways |
| spellingShingle | Mingyu Han Sui Li Huali Fan Junsha An Cheng Peng Fu Peng Fu Peng Regulated cell death in glioma: promising targets for natural small-molecule compounds Frontiers in Oncology regulated cell death glioma natural small-molecule compounds regulatory factors pathways |
| title | Regulated cell death in glioma: promising targets for natural small-molecule compounds |
| title_full | Regulated cell death in glioma: promising targets for natural small-molecule compounds |
| title_fullStr | Regulated cell death in glioma: promising targets for natural small-molecule compounds |
| title_full_unstemmed | Regulated cell death in glioma: promising targets for natural small-molecule compounds |
| title_short | Regulated cell death in glioma: promising targets for natural small-molecule compounds |
| title_sort | regulated cell death in glioma promising targets for natural small molecule compounds |
| topic | regulated cell death glioma natural small-molecule compounds regulatory factors pathways |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1273841/full |
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