Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement
Osteoporosis is a chronic disease requiring long-term treatment aimed at reducing the risk of low-energy fractures, by improving the quality and strength of bones when taking this or that drug. Bisphosphonates (BPs) are deposited in the bone, so that they have an aftereffect. Due to the increased ri...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2018-12-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/863 |
| _version_ | 1797876739924295680 |
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| author | N. V. Toroptsova |
| author_facet | N. V. Toroptsova |
| author_sort | N. V. Toroptsova |
| collection | DOAJ |
| description | Osteoporosis is a chronic disease requiring long-term treatment aimed at reducing the risk of low-energy fractures, by improving the quality and strength of bones when taking this or that drug. Bisphosphonates (BPs) are deposited in the bone, so that they have an aftereffect. Due to the increased risk of adverse reactions with BPs, the author considers that the patients may take a drug holiday or be switched to alternative therapy. Denosumab may be used continuously for years and, unlike BPs, does not require discontinuation. It is effective in both untreated and already BP-treated patients. At the same time, when the treatment is discontinued, the effect of denosumab is reversible; therefore, oral BP or intravenous zoledronic acid is recommended to maintain the achieved effect. |
| first_indexed | 2024-04-10T02:06:14Z |
| format | Article |
| id | doaj.art-4711dc21db1248959523c77f15c729a2 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:06:14Z |
| publishDate | 2018-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-4711dc21db1248959523c77f15c729a22023-03-13T08:39:26ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2018-12-01124596410.14412/1996-7012-2018-4-59-642127Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacementN. V. Toroptsova0ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».Osteoporosis is a chronic disease requiring long-term treatment aimed at reducing the risk of low-energy fractures, by improving the quality and strength of bones when taking this or that drug. Bisphosphonates (BPs) are deposited in the bone, so that they have an aftereffect. Due to the increased risk of adverse reactions with BPs, the author considers that the patients may take a drug holiday or be switched to alternative therapy. Denosumab may be used continuously for years and, unlike BPs, does not require discontinuation. It is effective in both untreated and already BP-treated patients. At the same time, when the treatment is discontinued, the effect of denosumab is reversible; therefore, oral BP or intravenous zoledronic acid is recommended to maintain the achieved effect.https://mrj.ima-press.net/mrj/article/view/863остеопорозлечениеденосумаббисфосфонатыприверженность лечениюдлительность лечения |
| spellingShingle | N. V. Toroptsova Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement Современная ревматология остеопороз лечение деносумаб бисфосфонаты приверженность лечению длительность лечения |
| title | Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement |
| title_full | Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement |
| title_fullStr | Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement |
| title_full_unstemmed | Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement |
| title_short | Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement |
| title_sort | treatment of patients with osteoporosis issues of therapy duration adherence and replacement |
| topic | остеопороз лечение деносумаб бисфосфонаты приверженность лечению длительность лечения |
| url | https://mrj.ima-press.net/mrj/article/view/863 |
| work_keys_str_mv | AT nvtoroptsova treatmentofpatientswithosteoporosisissuesoftherapydurationadherenceandreplacement |