Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular
The generation of reactive oxygen species (ROS) may be both beneficial to cells, performing functions in intracellular signaling and detrimental, modifying cellular biomolecules. ROS can cause DNA damage, such as base damage and strand breaks. Organisms respond to chromosome insults by activation of...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2006-12-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600032&lng=en&tlng=en |
| _version_ | 1811191809245708288 |
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| author | Carolina M. Berra Carlos F. M. Menck Paolo Di Mascio |
| author_facet | Carolina M. Berra Carlos F. M. Menck Paolo Di Mascio |
| author_sort | Carolina M. Berra |
| collection | DOAJ |
| description | The generation of reactive oxygen species (ROS) may be both beneficial to cells, performing functions in intracellular signaling and detrimental, modifying cellular biomolecules. ROS can cause DNA damage, such as base damage and strand breaks. Organisms respond to chromosome insults by activation of a complex and hierarchical DNA-damage response pathway. The extent of DNA damages determines cell fate: cell cycle arrest and DNA repair or cell death. The ATM is a central protein in the response to DNA double-strand breaks by acting as a transducer protein. Collected evidences suggest that ATM is also involved in the response to oxidative DNA damage. |
| first_indexed | 2024-04-11T23:43:13Z |
| format | Article |
| id | doaj.art-4716fd70cd74455b9e4c74036ed321e1 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-11T23:43:13Z |
| publishDate | 2006-12-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-4716fd70cd74455b9e4c74036ed321e12022-12-22T03:56:44ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642006-12-012961340134410.1590/S0100-40422006000600032S0100-40422006000600032Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celularCarolina M. Berra0Carlos F. M. Menck1Paolo Di Mascio2Universidade de São PauloUniversidade de São PauloUniversidade de São PauloThe generation of reactive oxygen species (ROS) may be both beneficial to cells, performing functions in intracellular signaling and detrimental, modifying cellular biomolecules. ROS can cause DNA damage, such as base damage and strand breaks. Organisms respond to chromosome insults by activation of a complex and hierarchical DNA-damage response pathway. The extent of DNA damages determines cell fate: cell cycle arrest and DNA repair or cell death. The ATM is a central protein in the response to DNA double-strand breaks by acting as a transducer protein. Collected evidences suggest that ATM is also involved in the response to oxidative DNA damage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600032&lng=en&tlng=enATMcheckpointsoxidative stress |
| spellingShingle | Carolina M. Berra Carlos F. M. Menck Paolo Di Mascio Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular Química Nova ATM checkpoints oxidative stress |
| title | Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular |
| title_full | Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular |
| title_fullStr | Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular |
| title_full_unstemmed | Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular |
| title_short | Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular |
| title_sort | estresse oxidativo lesoes no genoma e processos de sinalizacao no controle do ciclo celular |
| topic | ATM checkpoints oxidative stress |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600032&lng=en&tlng=en |
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