The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression
The high mortality from lung cancer is mainly attributed to the presence of metastases at the time of diagnosis. Despite being the leading cause of lung cancer death, the underlying molecular mechanisms driving metastasis progression are still not fully understood. Recent studies suggest that tumor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/11/1574 |
| _version_ | 1797459966866489344 |
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| author | Israel Martinez-Espinosa José Antonio Serrato Blanca Ortiz-Quintero |
| author_facet | Israel Martinez-Espinosa José Antonio Serrato Blanca Ortiz-Quintero |
| author_sort | Israel Martinez-Espinosa |
| collection | DOAJ |
| description | The high mortality from lung cancer is mainly attributed to the presence of metastases at the time of diagnosis. Despite being the leading cause of lung cancer death, the underlying molecular mechanisms driving metastasis progression are still not fully understood. Recent studies suggest that tumor cell exosomes play a significant role in tumor progression through intercellular communication between tumor cells, the microenvironment, and distant organs. Furthermore, evidence shows that exosomes release biologically active components to distant sites and organs, which direct metastasis by preparing metastatic pre-niche and stimulating tumorigenesis. As a result, identifying the active components of exosome cargo has become a critical area of research in recent years. Among these components are microRNAs, which are associated with tumor progression and metastasis in lung cancer. Although research into exosome-derived microRNA (exosomal miRNAs) is still in its early stages, it holds promise as a potential target for lung cancer therapy. Understanding how exosomal microRNAs promote metastasis will provide evidence for developing new targeted treatments. This review summarizes current research on exosomal miRNAs’ role in metastasis progression mechanisms, focusing on lung cancer. |
| first_indexed | 2024-03-09T16:59:22Z |
| format | Article |
| id | doaj.art-47178fc19afe4c3c8e8e92ad64147532 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T16:59:22Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-47178fc19afe4c3c8e8e92ad641475322023-11-24T14:31:47ZengMDPI AGBiomolecules2218-273X2023-10-011311157410.3390/biom13111574The Role of Exosome-Derived microRNA on Lung Cancer Metastasis ProgressionIsrael Martinez-Espinosa0José Antonio Serrato1Blanca Ortiz-Quintero2Department of Molecular Biomedicine and Translational Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City CP 14080, MexicoDepartment of Molecular Biomedicine and Translational Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City CP 14080, MexicoDepartment of Molecular Biomedicine and Translational Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City CP 14080, MexicoThe high mortality from lung cancer is mainly attributed to the presence of metastases at the time of diagnosis. Despite being the leading cause of lung cancer death, the underlying molecular mechanisms driving metastasis progression are still not fully understood. Recent studies suggest that tumor cell exosomes play a significant role in tumor progression through intercellular communication between tumor cells, the microenvironment, and distant organs. Furthermore, evidence shows that exosomes release biologically active components to distant sites and organs, which direct metastasis by preparing metastatic pre-niche and stimulating tumorigenesis. As a result, identifying the active components of exosome cargo has become a critical area of research in recent years. Among these components are microRNAs, which are associated with tumor progression and metastasis in lung cancer. Although research into exosome-derived microRNA (exosomal miRNAs) is still in its early stages, it holds promise as a potential target for lung cancer therapy. Understanding how exosomal microRNAs promote metastasis will provide evidence for developing new targeted treatments. This review summarizes current research on exosomal miRNAs’ role in metastasis progression mechanisms, focusing on lung cancer.https://www.mdpi.com/2218-273X/13/11/1574exosomemicroRNAlung cancermetastasis |
| spellingShingle | Israel Martinez-Espinosa José Antonio Serrato Blanca Ortiz-Quintero The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression Biomolecules exosome microRNA lung cancer metastasis |
| title | The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression |
| title_full | The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression |
| title_fullStr | The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression |
| title_full_unstemmed | The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression |
| title_short | The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression |
| title_sort | role of exosome derived microrna on lung cancer metastasis progression |
| topic | exosome microRNA lung cancer metastasis |
| url | https://www.mdpi.com/2218-273X/13/11/1574 |
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