Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese Individuals
INTRODUCTION: Obesity, which is defined as excessive and abnormal accumulation of adipose tissue, can lead to various systemic diseases beyond the deterioration of the quality of life of individuals. In this study, we aimed to compare the biochemical parameters, the presence of hepatosteatosis, non-...
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| Format: | Article |
| Language: | English |
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Kare Publishing
2023-09-01
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| Series: | Boğaziçi Tıp Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=bmj&un=BMJ-24482 |
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| author | Şencay Yıldız Şahin Saliha Yusufoğlu Sevim Özdemir Mehmet Koçak Hayriye Esra Ataoğlu |
| author_facet | Şencay Yıldız Şahin Saliha Yusufoğlu Sevim Özdemir Mehmet Koçak Hayriye Esra Ataoğlu |
| author_sort | Şencay Yıldız Şahin |
| collection | DOAJ |
| description | INTRODUCTION: Obesity, which is defined as excessive and abnormal accumulation of adipose tissue, can lead to various systemic diseases beyond the deterioration of the quality of life of individuals. In this study, we aimed to compare the biochemical parameters, the presence of hepatosteatosis, non-invasive liver fibrous scores (NAFLD), and common carotid artery (CCA) media thickness in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO). METHODS: Charts of patients who were admitted to the internal medicine outpatient clinic between June 2018 and June 2019 were retrospectively evaluated. Patients with body mass index ≥30 kg/m2 were evaluated for inclusion in the study. Participants were divided into two groups as MHO and MUHO, according to the Third National Health and Nutrition Examination Survey III criteria. The presence of liver fibrosis was calculated using NAFLD fibrosis score (NFS) and Fib-4 score. Patients categorized as MHO and MUHO were compared according to demographic characteristics, biochemical parameters, and radiological findings. RESULTS: Totally, 123 obese patients were enrolled into the study, and 95 patients were classified as MUHO. CCA was measured as 0.6 mm in MHO and 0.7 mm in MHUO, and the difference was statically significant in favor of MHO (p<0.001). Homeostatic model assessment of insulin resistance (HOMA-IR), insulin level, and triglyceride/glucose index (TyG) index were significantly higher in MUHO. The difference of Fib-4 indexes in MHO and MUHO was not statistically significant (p=0.100). However, NFS was significantly better in MHO (p<0.001). DISCUSSION AND CONCLUSION: The present study showed that almost four out of five obese patients were classified as MUHO. In addition, levels of glutamyl transferase, HOMA-IR, insulin, and TyG index were significantly higher in MUHO in comparison with MHO. Moreover, MUHO cases had significantly higher CCA media thickness levels, liver size, and worse NFS. |
| first_indexed | 2024-03-11T15:51:50Z |
| format | Article |
| id | doaj.art-4719835e483245c1bc1d8c7c9bda0eaf |
| institution | Directory Open Access Journal |
| issn | 2149-0287 |
| language | English |
| last_indexed | 2024-03-11T15:51:50Z |
| publishDate | 2023-09-01 |
| publisher | Kare Publishing |
| record_format | Article |
| series | Boğaziçi Tıp Dergisi |
| spelling | doaj.art-4719835e483245c1bc1d8c7c9bda0eaf2023-10-25T18:48:16ZengKare PublishingBoğaziçi Tıp Dergisi2149-02872023-09-0110315315810.14744/bmj.2023.24482BMJ-24482Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese IndividualsŞencay Yıldız Şahin0Saliha Yusufoğlu1Sevim Özdemir2Mehmet Koçak3Hayriye Esra Ataoğlu4Department of Internal Medicine, Sultangazi Haseki Training and Research Hospital, İstanbul, TürkiyeDepartment of Internal Medicine, Baykan State Hospital, Siirt, TürkiyeDepartment of Internal Medicine, Sultangazi Haseki Training and Research Hospital, İstanbul, TürkiyeDepartment of Emergency Medicine, Fatih Sultan Mehmet Training and Research Hospital, İstanbul, TürkiyeDepartment of Internal Medicine, Sultangazi Haseki Training and Research Hospital, İstanbul, TürkiyeINTRODUCTION: Obesity, which is defined as excessive and abnormal accumulation of adipose tissue, can lead to various systemic diseases beyond the deterioration of the quality of life of individuals. In this study, we aimed to compare the biochemical parameters, the presence of hepatosteatosis, non-invasive liver fibrous scores (NAFLD), and common carotid artery (CCA) media thickness in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO). METHODS: Charts of patients who were admitted to the internal medicine outpatient clinic between June 2018 and June 2019 were retrospectively evaluated. Patients with body mass index ≥30 kg/m2 were evaluated for inclusion in the study. Participants were divided into two groups as MHO and MUHO, according to the Third National Health and Nutrition Examination Survey III criteria. The presence of liver fibrosis was calculated using NAFLD fibrosis score (NFS) and Fib-4 score. Patients categorized as MHO and MUHO were compared according to demographic characteristics, biochemical parameters, and radiological findings. RESULTS: Totally, 123 obese patients were enrolled into the study, and 95 patients were classified as MUHO. CCA was measured as 0.6 mm in MHO and 0.7 mm in MHUO, and the difference was statically significant in favor of MHO (p<0.001). Homeostatic model assessment of insulin resistance (HOMA-IR), insulin level, and triglyceride/glucose index (TyG) index were significantly higher in MUHO. The difference of Fib-4 indexes in MHO and MUHO was not statistically significant (p=0.100). However, NFS was significantly better in MHO (p<0.001). DISCUSSION AND CONCLUSION: The present study showed that almost four out of five obese patients were classified as MUHO. In addition, levels of glutamyl transferase, HOMA-IR, insulin, and TyG index were significantly higher in MUHO in comparison with MHO. Moreover, MUHO cases had significantly higher CCA media thickness levels, liver size, and worse NFS.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=bmj&un=BMJ-24482healthy obesityhomeostatic model assessment of insulin resistancenon-alcoholic fatty liver diseasenon-invasive liver fibrous scorestriglyceride/glucose index. |
| spellingShingle | Şencay Yıldız Şahin Saliha Yusufoğlu Sevim Özdemir Mehmet Koçak Hayriye Esra Ataoğlu Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese Individuals Boğaziçi Tıp Dergisi healthy obesity homeostatic model assessment of insulin resistance non-alcoholic fatty liver disease non-invasive liver fibrous scores triglyceride/glucose index. |
| title | Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese Individuals |
| title_full | Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese Individuals |
| title_fullStr | Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese Individuals |
| title_full_unstemmed | Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese Individuals |
| title_short | Markers of Non-alcoholic Fatty Liver Disease Among Metabolically Healthy and Unhealthy Obese Individuals |
| title_sort | markers of non alcoholic fatty liver disease among metabolically healthy and unhealthy obese individuals |
| topic | healthy obesity homeostatic model assessment of insulin resistance non-alcoholic fatty liver disease non-invasive liver fibrous scores triglyceride/glucose index. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=bmj&un=BMJ-24482 |
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