Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

<p>Abstract</p> <p>Background</p> <p>Toll-like receptor 4 (TLR4) is activated by bacterial endotoxin, a prototypical pathogen-associated molecular pattern (PAMP). It has been suggested that TLR4 can also be activated by damage-associated molecular pattern (DAMP) protein...

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Bibliographic Details
Main Authors: Luong Michael, Zhang Yanyu, Chamberlain Tim, Zhou Tianhui, Wright Jill F, Dower Ken, Hall J Perry
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Journal of Inflammation
Subjects:
Endotoxin
Heat shock protein 70
Polymyxin B
Proteinase K
TLR4
Online Access:http://www.journal-inflammation.com/content/9/1/11

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