G-Protein Coupled Receptor Dysregulation May Play Roles in Severe Preeclampsia—A Weighted Gene Correlation Network Analysis of Placental Gene Expression Profile

G-Protein Coupled Receptor Dysregulation May Play Roles in Severe Preeclampsia—A Weighted Gene Correlation Network Analysis of Placental Gene Expression Profile

Preeclampsia is one of the major hypertensive diseases of pregnancy. Genetic factors contribute to abnormal placentation. The inadequate transformation of cytotrophoblasts causes failure of maternal spiral arteries’ remodeling and results in narrow, atherotic-prone vessels, leading to relative place...

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Bibliographic Details
Main Authors: Manuel S. Vidal, Christian Deo T. Deguit, Gracia Fe B. Yu, Melissa D. Amosco
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
preeclampsia
G-protein-coupled receptors
GPCR
weighted gene correlation network analysis
WGCNA
Online Access:https://www.mdpi.com/2073-4409/11/5/763

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