Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial
Violet light (VL), 360–400 nm wavelength, is contained in the sunlight and is an effective element for myopia suppression. This study is to investigate the safety and efficacy of novel eyeglasses that emit VL from the frames. This is a double-masked, randomized, pilot clinical trial conducted in a c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/20/6000 |
| _version_ | 1797472509223763968 |
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| author | Hidemasa Torii Kiwako Mori Takashi Okano Shinichiro Kondo Hao-Yung Yang Erisa Yotsukura Akiko Hanyuda Mamoru Ogawa Kazuno Negishi Toshihide Kurihara Kazuo Tsubota |
| author_facet | Hidemasa Torii Kiwako Mori Takashi Okano Shinichiro Kondo Hao-Yung Yang Erisa Yotsukura Akiko Hanyuda Mamoru Ogawa Kazuno Negishi Toshihide Kurihara Kazuo Tsubota |
| author_sort | Hidemasa Torii |
| collection | DOAJ |
| description | Violet light (VL), 360–400 nm wavelength, is contained in the sunlight and is an effective element for myopia suppression. This study is to investigate the safety and efficacy of novel eyeglasses that emit VL from the frames. This is a double-masked, randomized, pilot clinical trial conducted in a clinic in Japan. Forty-three children with myopia were enrolled. Participants were randomly assigned to two groups, wearing VL-emitting eyeglass frames (VLf) that emitted VL of 310 μW/cm<sup>2</sup> (VLf group, <i>n</i> = 22) or pseudo-placebo eyeglass frames with a minimal emission of VL (<10 μW/cm<sup>2</sup>) (control group, <i>n</i> = 21). The exposure time was 3 h per day. The primary outcomes were visual acuity, tear film break-up time, corneal endothelial cell density, and the slit-lamp/fundus examinations. The secondary outcome was the 6-month changes in the axial lengths and cycloplegic refractions. Forty-one (95%) participants were included; twenty-one in the VLf group and twenty in the control group. No significant differences were seen in any safety evaluation. Significant changes were seen in axial elongation, choroidal thickness, and cycloplegic refractions in the subgroup analysis of 8- to 10-year-old children (<i>p</i> < 0.05), but otherwise no significant differences were seen. The VLf showed short-term safety and effectiveness against myopia progression. |
| first_indexed | 2024-03-09T20:02:45Z |
| format | Article |
| id | doaj.art-471b243bf3c34648b5981f6a9a30cc59 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:02:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-471b243bf3c34648b5981f6a9a30cc592023-11-24T00:39:17ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011120600010.3390/jcm11206000Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical TrialHidemasa Torii0Kiwako Mori1Takashi Okano2Shinichiro Kondo3Hao-Yung Yang4Erisa Yotsukura5Akiko Hanyuda6Mamoru Ogawa7Kazuno Negishi8Toshihide Kurihara9Kazuo Tsubota10Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanSmile Eye Clinic, Kanzeme Building 4F, 1-6-12 Aoba-ku, Yokohama 227-0062, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanSmile Eye Clinic, Kanzeme Building 4F, 1-6-12 Aoba-ku, Yokohama 227-0062, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanViolet light (VL), 360–400 nm wavelength, is contained in the sunlight and is an effective element for myopia suppression. This study is to investigate the safety and efficacy of novel eyeglasses that emit VL from the frames. This is a double-masked, randomized, pilot clinical trial conducted in a clinic in Japan. Forty-three children with myopia were enrolled. Participants were randomly assigned to two groups, wearing VL-emitting eyeglass frames (VLf) that emitted VL of 310 μW/cm<sup>2</sup> (VLf group, <i>n</i> = 22) or pseudo-placebo eyeglass frames with a minimal emission of VL (<10 μW/cm<sup>2</sup>) (control group, <i>n</i> = 21). The exposure time was 3 h per day. The primary outcomes were visual acuity, tear film break-up time, corneal endothelial cell density, and the slit-lamp/fundus examinations. The secondary outcome was the 6-month changes in the axial lengths and cycloplegic refractions. Forty-one (95%) participants were included; twenty-one in the VLf group and twenty in the control group. No significant differences were seen in any safety evaluation. Significant changes were seen in axial elongation, choroidal thickness, and cycloplegic refractions in the subgroup analysis of 8- to 10-year-old children (<i>p</i> < 0.05), but otherwise no significant differences were seen. The VLf showed short-term safety and effectiveness against myopia progression.https://www.mdpi.com/2077-0383/11/20/6000myopiaviolet lightrandomized double-blind placebo-controlled clinical trialsafetyefficacy |
| spellingShingle | Hidemasa Torii Kiwako Mori Takashi Okano Shinichiro Kondo Hao-Yung Yang Erisa Yotsukura Akiko Hanyuda Mamoru Ogawa Kazuno Negishi Toshihide Kurihara Kazuo Tsubota Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial Journal of Clinical Medicine myopia violet light randomized double-blind placebo-controlled clinical trial safety efficacy |
| title | Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial |
| title_full | Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial |
| title_fullStr | Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial |
| title_full_unstemmed | Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial |
| title_short | Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial |
| title_sort | short term exposure to violet light emitted from eyeglass frames in myopic children a randomized pilot clinical trial |
| topic | myopia violet light randomized double-blind placebo-controlled clinical trial safety efficacy |
| url | https://www.mdpi.com/2077-0383/11/20/6000 |
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