2-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazide
A synthesis of 2-((4-phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>’-(1-phenylethylidene)acetohydrazide from 2-[(3-{2-[(4-methylphenyl)amino]ethyl}-4-phenyl-4,5-dihydro-1<i>H</i>-1,2,4-triazol-5-yl)sulfanyl]acetohyd...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2022/2/M1380 |
| _version_ | 1797484123746467840 |
|---|---|
| author | Aida Šermukšnytė Ilona Jonuškienė Kristina Kantminienė Zigmuntas Jonas Beresnevičius Ingrida Tumosienė |
| author_facet | Aida Šermukšnytė Ilona Jonuškienė Kristina Kantminienė Zigmuntas Jonas Beresnevičius Ingrida Tumosienė |
| author_sort | Aida Šermukšnytė |
| collection | DOAJ |
| description | A synthesis of 2-((4-phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>’-(1-phenylethylidene)acetohydrazide from 2-[(3-{2-[(4-methylphenyl)amino]ethyl}-4-phenyl-4,5-dihydro-1<i>H</i>-1,2,4-triazol-5-yl)sulfanyl]acetohydrazide and acetophenone is reported. The title compound has been tested to possess 1.5-fold higher antioxidant ability than the control, butylated hydroxytoluene, as determined by a Ferric reducing antioxidant power assay. |
| first_indexed | 2024-03-09T22:56:59Z |
| format | Article |
| id | doaj.art-471ec0a9406f4a7c9f191e463b28fa47 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-09T22:56:59Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-471ec0a9406f4a7c9f191e463b28fa472023-11-23T18:08:34ZengMDPI AGMolbank1422-85992022-06-0120222M138010.3390/M13802-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazideAida Šermukšnytė0Ilona Jonuškienė1Kristina Kantminienė2Zigmuntas Jonas Beresnevičius3Ingrida Tumosienė4Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, LithuaniaDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, LithuaniaDepartment of Physical and Inorganic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, LithuaniaDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, LithuaniaDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, LithuaniaA synthesis of 2-((4-phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>’-(1-phenylethylidene)acetohydrazide from 2-[(3-{2-[(4-methylphenyl)amino]ethyl}-4-phenyl-4,5-dihydro-1<i>H</i>-1,2,4-triazol-5-yl)sulfanyl]acetohydrazide and acetophenone is reported. The title compound has been tested to possess 1.5-fold higher antioxidant ability than the control, butylated hydroxytoluene, as determined by a Ferric reducing antioxidant power assay.https://www.mdpi.com/1422-8599/2022/2/M13801,2,4-triazolehydrazoneSchiff baseantioxidativeferric reducing antioxidant power (FRAP) assay |
| spellingShingle | Aida Šermukšnytė Ilona Jonuškienė Kristina Kantminienė Zigmuntas Jonas Beresnevičius Ingrida Tumosienė 2-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazide Molbank 1,2,4-triazole hydrazone Schiff base antioxidative ferric reducing antioxidant power (FRAP) assay |
| title | 2-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazide |
| title_full | 2-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazide |
| title_fullStr | 2-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazide |
| title_full_unstemmed | 2-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazide |
| title_short | 2-((4-Phenyl-5-(2-(<i>p</i>-tolylamino)ethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio)-<i>N</i>′-(1-phenylethylidene)acetohydrazide |
| title_sort | 2 4 phenyl 5 2 i p i tolylamino ethyl 4 i h i 1 2 4 triazol 3 yl thio i n i 1 phenylethylidene acetohydrazide |
| topic | 1,2,4-triazole hydrazone Schiff base antioxidative ferric reducing antioxidant power (FRAP) assay |
| url | https://www.mdpi.com/1422-8599/2022/2/M1380 |
| work_keys_str_mv | AT aidasermuksnyte 24phenyl52ipitolylaminoethyl4ihi124triazol3ylthioini1phenylethylideneacetohydrazide AT ilonajonuskiene 24phenyl52ipitolylaminoethyl4ihi124triazol3ylthioini1phenylethylideneacetohydrazide AT kristinakantminiene 24phenyl52ipitolylaminoethyl4ihi124triazol3ylthioini1phenylethylideneacetohydrazide AT zigmuntasjonasberesnevicius 24phenyl52ipitolylaminoethyl4ihi124triazol3ylthioini1phenylethylideneacetohydrazide AT ingridatumosiene 24phenyl52ipitolylaminoethyl4ihi124triazol3ylthioini1phenylethylideneacetohydrazide |