Ion-ing out the genetic variants of Kir2.1
Deep mutational scanning provides new insights into how mutations alter the expression and activity of the potassium ion channel Kir2.1, which is associated with many diseases.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2022-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/80718 |
| _version_ | 1811252364840009728 |
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| author | Braden S Fallon Justin G English |
| author_facet | Braden S Fallon Justin G English |
| author_sort | Braden S Fallon |
| collection | DOAJ |
| description | Deep mutational scanning provides new insights into how mutations alter the expression and activity of the potassium ion channel Kir2.1, which is associated with many diseases. |
| first_indexed | 2024-04-12T16:34:31Z |
| format | Article |
| id | doaj.art-471ffbf071f24931983c2ece63b46626 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:34:31Z |
| publishDate | 2022-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-471ffbf071f24931983c2ece63b466262022-12-22T03:25:02ZengeLife Sciences Publications LtdeLife2050-084X2022-07-011110.7554/eLife.80718Ion-ing out the genetic variants of Kir2.1Braden S Fallon0https://orcid.org/0000-0001-8308-418XJustin G English1https://orcid.org/0000-0002-1161-8928Department of Biochemistry, University of Utah, Salt Lake City, United StatesDepartment of Biochemistry, University of Utah, Salt Lake City, United StatesDeep mutational scanning provides new insights into how mutations alter the expression and activity of the potassium ion channel Kir2.1, which is associated with many diseases.https://elifesciences.org/articles/80718deep mutational scanningion channelfoldinggatinghigh-throughputvariant effect prediction |
| spellingShingle | Braden S Fallon Justin G English Ion-ing out the genetic variants of Kir2.1 eLife deep mutational scanning ion channel folding gating high-throughput variant effect prediction |
| title | Ion-ing out the genetic variants of Kir2.1 |
| title_full | Ion-ing out the genetic variants of Kir2.1 |
| title_fullStr | Ion-ing out the genetic variants of Kir2.1 |
| title_full_unstemmed | Ion-ing out the genetic variants of Kir2.1 |
| title_short | Ion-ing out the genetic variants of Kir2.1 |
| title_sort | ion ing out the genetic variants of kir2 1 |
| topic | deep mutational scanning ion channel folding gating high-throughput variant effect prediction |
| url | https://elifesciences.org/articles/80718 |
| work_keys_str_mv | AT bradensfallon ioningoutthegeneticvariantsofkir21 AT justingenglish ioningoutthegeneticvariantsofkir21 |