Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs
Abstract Background A great number of sedatives and anaesthetics have been used to perform surgeries or routine ophthalmologic examinations in animals and sometimes the combination of these medicines has more suitable effects than each one alone. Objectives This paper aims to explore the main effect...
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Veterinary Medicine and Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/vms3.467 |
| _version_ | 1819145644951994368 |
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| author | Ali Aghababaei Ali Ronagh Bahman Mosallanejad Ali Baniadam |
| author_facet | Ali Aghababaei Ali Ronagh Bahman Mosallanejad Ali Baniadam |
| author_sort | Ali Aghababaei |
| collection | DOAJ |
| description | Abstract Background A great number of sedatives and anaesthetics have been used to perform surgeries or routine ophthalmologic examinations in animals and sometimes the combination of these medicines has more suitable effects than each one alone. Objectives This paper aims to explore the main effects of Medetomidine + Acepromazine, Dexmedetomidine + Acepromazine on intraocular pressure, tear secretion and pupil diameter. Methods To accomplish the aforementioned aim, 32 adult dogs (aged one‐to‐three‐years‐old) were clinically examined. Dogs were divided into four groups consisting of group DA, Dexmedetomidine (5 µg/kg) + Acepromazine (0.05 mg/kg); Group D, Dexmedetomidine (5 µg/kg); Group M, Medetomidine (10 µg/kg); Group MA, Medetomidine (10 µg/kg) + Acepromazine (0.05 mg/kg). The ocular factors including tear production, pupil diameter and intraocular pressure of both right and left eyes were first measured and then recorded in each dog at time T0 (−15 min). Afterwards, the drugs were administered intramuscularly, based on which the ocular factors were re‐measured at T1 (+5 min), T2 (+15 min) and T3 (+20 min). All four groups showed a reduction in intraocular pressure, which was significant in DA, D and M groups. Results Furthermore, there was a fluctuation in the amount of tear secretion in DA and D groups (increase and then decrease), as well as a significant reduction in M and MA groups. Decreasing in pupil diameter also occurred in all four groups, but the reduction was significant only in DA and MA groups. Conclusion According to the results obtained, as the changes caused by the systemic administration of the above drug compounds did not exceed the physiological range, it can be concluded that these combinations could be utilized as suitable sedatives or pre‐anaesthetic compounds in the eye surgeries. |
| first_indexed | 2024-12-22T13:01:19Z |
| format | Article |
| id | doaj.art-47202b3fb3ab42beb72293a40547d3c6 |
| institution | Directory Open Access Journal |
| issn | 2053-1095 |
| language | English |
| last_indexed | 2024-12-22T13:01:19Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj.art-47202b3fb3ab42beb72293a40547d3c62022-12-21T18:25:00ZengWileyVeterinary Medicine and Science2053-10952021-07-01741090109510.1002/vms3.467Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogsAli Aghababaei0Ali Ronagh1Bahman Mosallanejad2Ali Baniadam3Graduate of Doctor of Veterinary Medicine Faculty of Veterinary Medicine Shahid Chamran University of Ahvaz Ahvaz IranDepartment of Clinical Sciences Faculty of Veterinary Medicine Shahid Chamran University of Ahvaz Ahvaz IranDepartment of Clinical Sciences Faculty of Veterinary Medicine Shahid Chamran University of Ahvaz Ahvaz IranDepartment of Clinical Sciences Faculty of Veterinary Medicine Shahid Chamran University of Ahvaz Ahvaz IranAbstract Background A great number of sedatives and anaesthetics have been used to perform surgeries or routine ophthalmologic examinations in animals and sometimes the combination of these medicines has more suitable effects than each one alone. Objectives This paper aims to explore the main effects of Medetomidine + Acepromazine, Dexmedetomidine + Acepromazine on intraocular pressure, tear secretion and pupil diameter. Methods To accomplish the aforementioned aim, 32 adult dogs (aged one‐to‐three‐years‐old) were clinically examined. Dogs were divided into four groups consisting of group DA, Dexmedetomidine (5 µg/kg) + Acepromazine (0.05 mg/kg); Group D, Dexmedetomidine (5 µg/kg); Group M, Medetomidine (10 µg/kg); Group MA, Medetomidine (10 µg/kg) + Acepromazine (0.05 mg/kg). The ocular factors including tear production, pupil diameter and intraocular pressure of both right and left eyes were first measured and then recorded in each dog at time T0 (−15 min). Afterwards, the drugs were administered intramuscularly, based on which the ocular factors were re‐measured at T1 (+5 min), T2 (+15 min) and T3 (+20 min). All four groups showed a reduction in intraocular pressure, which was significant in DA, D and M groups. Results Furthermore, there was a fluctuation in the amount of tear secretion in DA and D groups (increase and then decrease), as well as a significant reduction in M and MA groups. Decreasing in pupil diameter also occurred in all four groups, but the reduction was significant only in DA and MA groups. Conclusion According to the results obtained, as the changes caused by the systemic administration of the above drug compounds did not exceed the physiological range, it can be concluded that these combinations could be utilized as suitable sedatives or pre‐anaesthetic compounds in the eye surgeries.https://doi.org/10.1002/vms3.467AcepromazineDexmedetomidinedogintraocular pressure (IOP)Medetomidine |
| spellingShingle | Ali Aghababaei Ali Ronagh Bahman Mosallanejad Ali Baniadam Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs Veterinary Medicine and Science Acepromazine Dexmedetomidine dog intraocular pressure (IOP) Medetomidine |
| title | Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs |
| title_full | Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs |
| title_fullStr | Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs |
| title_full_unstemmed | Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs |
| title_short | Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs |
| title_sort | effects of medetomidine dexmedetomidine and their combination with acepromazine on the intraocular pressure iop tear secretion and pupil diameter in dogs |
| topic | Acepromazine Dexmedetomidine dog intraocular pressure (IOP) Medetomidine |
| url | https://doi.org/10.1002/vms3.467 |
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