Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes
Abstract Background Environmental exposures have been associated with the juvenile idiopathic inflammatory myopathies (JIIM). We undertook a questionnaire-based study to evaluate patient-reported exposures as possible risk factors for JIIM. Findings One-hundred-seven patients with JIIM were enrolled...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Pediatric Rheumatology Online Journal |
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| Online Access: | https://doi.org/10.1186/s12969-022-00684-9 |
| _version_ | 1818273399428874240 |
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| author | Jonathan C. Scalabrini Adam I. Schiffenbauer Payam Noroozi Farhadi Rita Volochayev Nastaran Bayat Anna Jansen Ira N. Targoff Frederick W. Miller Lisa G. Rider |
| author_facet | Jonathan C. Scalabrini Adam I. Schiffenbauer Payam Noroozi Farhadi Rita Volochayev Nastaran Bayat Anna Jansen Ira N. Targoff Frederick W. Miller Lisa G. Rider |
| author_sort | Jonathan C. Scalabrini |
| collection | DOAJ |
| description | Abstract Background Environmental exposures have been associated with the juvenile idiopathic inflammatory myopathies (JIIM). We undertook a questionnaire-based study to evaluate patient-reported exposures as possible risk factors for JIIM. Findings One-hundred-seven patients with JIIM were enrolled in a myositis natural history protocol and completed environmental questionnaires. Frequencies of exposures in clinical and myositis-specific autoantibody (MSA) groups were examined. Patients with juvenile dermatomyositis (JDM) and juvenile connective tissue myositis (JCTM) more frequently received an immunization within 1 year of diagnosis compared to juvenile polymyositis (57.5 and 71.4% vs 0.0%, p ≤ 0.017). JCTM patients were more often underweight at diagnosis relative to JDM patients (42.9% vs 7.0%, p = 0.002). MSA-negative patients more frequently had gastroenteritis within a year of diagnosis compared to patients with anti-MDA5 autoantibodies (28.6% vs 0.0%, p = 0.032). Heavy exercise was more frequent in MSA-negative and anti-MDA5 groups compared to the anti-TIF-1 autoantibody group (42.9 and 35.3% vs. 9.0%, p ≤ 0.047). Medications received within 1 year of diagnosis were more frequent in MSA-negative patients relative to those with anti-MDA5 autoantibodies (92.9% vs. 52.8% p = 0.045). Being breastfed > 6 months was more frequent in MSA-negative patients (88.9%) compared to anti-TIF-1 and anti-MDA5 autoantibody groups (41.2 and 28.6%, p ≤ 0.036). Conclusions Certain environmental exposures prior to diagnosis differed among clinical and serologic subgroups of JIIM, suggesting additional exposures to be explored as possible risk factors for JIIM phenotypes. |
| first_indexed | 2024-12-12T21:57:21Z |
| format | Article |
| id | doaj.art-47228ff9fb9d452f8be6c8e3eafc512e |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-12-12T21:57:21Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-47228ff9fb9d452f8be6c8e3eafc512e2022-12-22T00:10:36ZengBMCPediatric Rheumatology Online Journal1546-00962022-04-0120111010.1186/s12969-022-00684-9Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypesJonathan C. Scalabrini0Adam I. Schiffenbauer1Payam Noroozi Farhadi2Rita Volochayev3Nastaran Bayat4Anna Jansen5Ira N. Targoff6Frederick W. Miller7Lisa G. Rider8Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthVeteran’s Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research FoundationEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of HealthAbstract Background Environmental exposures have been associated with the juvenile idiopathic inflammatory myopathies (JIIM). We undertook a questionnaire-based study to evaluate patient-reported exposures as possible risk factors for JIIM. Findings One-hundred-seven patients with JIIM were enrolled in a myositis natural history protocol and completed environmental questionnaires. Frequencies of exposures in clinical and myositis-specific autoantibody (MSA) groups were examined. Patients with juvenile dermatomyositis (JDM) and juvenile connective tissue myositis (JCTM) more frequently received an immunization within 1 year of diagnosis compared to juvenile polymyositis (57.5 and 71.4% vs 0.0%, p ≤ 0.017). JCTM patients were more often underweight at diagnosis relative to JDM patients (42.9% vs 7.0%, p = 0.002). MSA-negative patients more frequently had gastroenteritis within a year of diagnosis compared to patients with anti-MDA5 autoantibodies (28.6% vs 0.0%, p = 0.032). Heavy exercise was more frequent in MSA-negative and anti-MDA5 groups compared to the anti-TIF-1 autoantibody group (42.9 and 35.3% vs. 9.0%, p ≤ 0.047). Medications received within 1 year of diagnosis were more frequent in MSA-negative patients relative to those with anti-MDA5 autoantibodies (92.9% vs. 52.8% p = 0.045). Being breastfed > 6 months was more frequent in MSA-negative patients (88.9%) compared to anti-TIF-1 and anti-MDA5 autoantibody groups (41.2 and 28.6%, p ≤ 0.036). Conclusions Certain environmental exposures prior to diagnosis differed among clinical and serologic subgroups of JIIM, suggesting additional exposures to be explored as possible risk factors for JIIM phenotypes.https://doi.org/10.1186/s12969-022-00684-9Juvenile myositisEnvironmental factorsPhenotypeMyositis autoantibodies |
| spellingShingle | Jonathan C. Scalabrini Adam I. Schiffenbauer Payam Noroozi Farhadi Rita Volochayev Nastaran Bayat Anna Jansen Ira N. Targoff Frederick W. Miller Lisa G. Rider Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes Pediatric Rheumatology Online Journal Juvenile myositis Environmental factors Phenotype Myositis autoantibodies |
| title | Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes |
| title_full | Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes |
| title_fullStr | Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes |
| title_full_unstemmed | Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes |
| title_short | Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes |
| title_sort | environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes |
| topic | Juvenile myositis Environmental factors Phenotype Myositis autoantibodies |
| url | https://doi.org/10.1186/s12969-022-00684-9 |
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