UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved]
Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wellcome
2019-10-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/4-118/v2 |
| _version_ | 1819108343645470720 |
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| author | Holly B. Bratcher Charlene M. C. Rodrigues Adam Finn Mandy Wootton J. Claire Cameron Andrew Smith Paul Heath Shamez Ladhani Matthew D. Snape Andrew J. Pollard Richard Cunningham Raymond Borrow Caroline Trotter Stephen J. Gray Martin C. J. Maiden Jenny M. MacLennan |
| author_facet | Holly B. Bratcher Charlene M. C. Rodrigues Adam Finn Mandy Wootton J. Claire Cameron Andrew Smith Paul Heath Shamez Ladhani Matthew D. Snape Andrew J. Pollard Richard Cunningham Raymond Borrow Caroline Trotter Stephen J. Gray Martin C. J. Maiden Jenny M. MacLennan |
| author_sort | Holly B. Bratcher |
| collection | DOAJ |
| description | Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here. |
| first_indexed | 2024-12-22T03:08:26Z |
| format | Article |
| id | doaj.art-4723d9d20b0f4c9a877aabb2fdf4743e |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-12-22T03:08:26Z |
| publishDate | 2019-10-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-4723d9d20b0f4c9a877aabb2fdf4743e2022-12-21T18:40:59ZengWellcomeWellcome Open Research2398-502X2019-10-01410.12688/wellcomeopenres.15362.217015UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved]Holly B. Bratcher0Charlene M. C. Rodrigues1Adam Finn2Mandy Wootton3J. Claire Cameron4Andrew Smith5Paul Heath6Shamez Ladhani7Matthew D. Snape8Andrew J. Pollard9Richard Cunningham10Raymond Borrow11Caroline Trotter12Stephen J. Gray13Martin C. J. Maiden14Jenny M. MacLennan15Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, OX1 3SY, UKPeter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, OX1 3SY, UKSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, BS2 8AE, UKDivision of Public Health Wales, Cardiff, CF10 3NW, UKNHS National Services Scotland, Health Protection Scotland, Glasgow, G2 6QE, UKUniversity of Glasgow Dental School, Glasgow, G2 3JZ, UKPaediatric Infectious Diseases Research Group, St George’s, University of London, London, SW17 0QT, UKPaediatric Infectious Diseases Research Group, St George’s, University of London, London, SW17 0QT, UKOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford Biomedical Research Centre, Oxford, OX3 7LE, UKOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford Biomedical Research Centre, Oxford, OX3 7LE, UKMicrobiology Department, University Hospitals Plymouth NHS Trust, Plymouth, PL6 8DH, UKMeningococcal Reference Unit, Public Health England, Manchester Royal Infirmary, Manchester, M13 9WL, UKDisease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UKMeningococcal Reference Unit, Public Health England, Manchester Royal Infirmary, Manchester, M13 9WL, UKPeter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, OX1 3SY, UKPeter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, OX1 3SY, UKCarriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here.https://wellcomeopenresearch.org/articles/4-118/v2 |
| spellingShingle | Holly B. Bratcher Charlene M. C. Rodrigues Adam Finn Mandy Wootton J. Claire Cameron Andrew Smith Paul Heath Shamez Ladhani Matthew D. Snape Andrew J. Pollard Richard Cunningham Raymond Borrow Caroline Trotter Stephen J. Gray Martin C. J. Maiden Jenny M. MacLennan UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved] Wellcome Open Research |
| title | UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved] |
| title_full | UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved] |
| title_fullStr | UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved] |
| title_full_unstemmed | UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved] |
| title_short | UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 2; peer review: 2 approved] |
| title_sort | ukmencar4 a cross sectional survey of asymptomatic meningococcal carriage amongst uk adolescents at a period of low invasive meningococcal disease incidence version 2 peer review 2 approved |
| url | https://wellcomeopenresearch.org/articles/4-118/v2 |
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