Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF

Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF

Abstract Background It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the casc...

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Bibliographic Details
Main Authors: Matthias F. Schneider, Mohammad A. Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim, Alfredo Alexander-Katz, Stefan W. Schneider, Volker Huck
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Molecular and Cell Biology
Subjects:
Von Willebrand factor
Platelet adhesion
Shear activation
Primary haemostasis
Online Access:http://link.springer.com/article/10.1186/s12860-020-00309-7

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