Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis
Denture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/2/230 |
| _version_ | 1797490933299675136 |
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| author | Salwa Omar Bajunaid Bashayer H. Baras Michael D. Weir Hockin H. K. Xu |
| author_facet | Salwa Omar Bajunaid Bashayer H. Baras Michael D. Weir Hockin H. K. Xu |
| author_sort | Salwa Omar Bajunaid |
| collection | DOAJ |
| description | Denture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) and dimethylaminohexadecyl methacrylate (DMAHDM) into a high impact polymethylmethacrylate heat-cured denture base acrylic resin as a potential treatment for denture stomatitis. We used a comparative study design to examine the effect of incorporating MPC as a protein repellent agent and DMAHDM as an antifungal agent to prevent the adherence of <i>Candida albicans</i> to the denture base material. The dual incorporation of MPC and DMAHDM reduced <i>C. albicans</i> biofilm colony-forming unit by two orders of magnitude when compared to the control group devoid of the bioactive agents. Although the addition of MPC and DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups. This new denture acrylic resin provides the benefit of enhancing <i>C. albicans</i> biofilm elimination through dual mechanisms of action, which could potentially reduce the prevalence of denture stomatitis. |
| first_indexed | 2024-03-10T00:40:09Z |
| format | Article |
| id | doaj.art-47244475ffd749ab808129739f9a55a9 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T00:40:09Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-47244475ffd749ab808129739f9a55a92023-11-23T15:08:11ZengMDPI AGPolymers2073-43602022-01-0114223010.3390/polym14020230Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture StomatitisSalwa Omar Bajunaid0Bashayer H. Baras1Michael D. Weir2Hockin H. K. Xu3Department of Prosthetic Sciences, College of Dentistry, King Saud University, Riyadh 60169-15, Saudi ArabiaDepartment of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh 60169-15, Saudi ArabiaDepartment of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, MD 21201, USADepartment of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, MD 21201, USADenture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) and dimethylaminohexadecyl methacrylate (DMAHDM) into a high impact polymethylmethacrylate heat-cured denture base acrylic resin as a potential treatment for denture stomatitis. We used a comparative study design to examine the effect of incorporating MPC as a protein repellent agent and DMAHDM as an antifungal agent to prevent the adherence of <i>Candida albicans</i> to the denture base material. The dual incorporation of MPC and DMAHDM reduced <i>C. albicans</i> biofilm colony-forming unit by two orders of magnitude when compared to the control group devoid of the bioactive agents. Although the addition of MPC and DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups. This new denture acrylic resin provides the benefit of enhancing <i>C. albicans</i> biofilm elimination through dual mechanisms of action, which could potentially reduce the prevalence of denture stomatitis.https://www.mdpi.com/2073-4360/14/2/230antifungalantimicrobial<i>Candida albicans</i>denture stomatitisflexural strengthsurface roughness |
| spellingShingle | Salwa Omar Bajunaid Bashayer H. Baras Michael D. Weir Hockin H. K. Xu Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis Polymers antifungal antimicrobial <i>Candida albicans</i> denture stomatitis flexural strength surface roughness |
| title | Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis |
| title_full | Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis |
| title_fullStr | Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis |
| title_full_unstemmed | Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis |
| title_short | Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis |
| title_sort | denture acrylic resin material with antibacterial and protein repelling properties for the prevention of denture stomatitis |
| topic | antifungal antimicrobial <i>Candida albicans</i> denture stomatitis flexural strength surface roughness |
| url | https://www.mdpi.com/2073-4360/14/2/230 |
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