Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures
T Iannitti,1,2 V Rottigni,2,3 B Palmieri2,31School of Biomedical Sciences, University of Leeds, Leeds, UK; 2Poliambulatorio del Secondo Parere, Modena, Italy; 3Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Ital...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-09-01
|
| Series: | Drug Design, Development and Therapy |
| Online Access: | http://www.dovepress.com/corticosteroid-transdermal-delivery-to-target-swelling-edema-and-infla-a14494 |
| _version_ | 1811263551125323776 |
|---|---|
| author | Iannitti T Rottigni V Palmieri B |
| author_facet | Iannitti T Rottigni V Palmieri B |
| author_sort | Iannitti T |
| collection | DOAJ |
| description | T Iannitti,1,2 V Rottigni,2,3 B Palmieri2,31School of Biomedical Sciences, University of Leeds, Leeds, UK; 2Poliambulatorio del Secondo Parere, Modena, Italy; 3Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, ItalyBackground and aim: The use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil®) to manage facial swelling, edema, inflammation, ecchymosis, and hematoma, when applied immediately after a facial rejuvenation procedure.Materials and methods: We applied the plaster to the skin of 20 healthy patients for 12 hours immediately after hyaluronic acid-based procedure performed with the aim of erasing facial wrinkles of perioral and nasolabial folds and improving chin and eye contour. A further 20 patients underwent the same cosmetic procedure, but they were treated with an aescin 10% cream (applied immediately after the procedure, in the evening, and the morning after) and served as control group.Results: Betesil® application resulted in a significant improvement in swelling/edema/inflammation score, if compared with aescin 10% cream (P < 0.01). As for facial ecchymosis and hematoma around the needle injection track, only two patients in the active treatment group displayed minimal ecchymosis and hematoma. In the control group, two patients presented minimal ecchymosis and three slight hematoma. However, using the ecchymosis/hematoma score, no significant difference between Betesil® and aescin 10% cream groups was observed. Patients’ satisfaction was significantly higher among subjects receiving Betesil®, if compared to patients receiving aescin 10% cream (P < 0.01).Conclusion: The present study supports the use of Betesil® plaster immediately after facial cosmetic procedures in order to safely control swelling, edema, and inflammation.Keywords: aesthetic medicine, transdermal therapeutic system, betamethasone valerate, hyaluronic acid |
| first_indexed | 2024-04-12T19:47:20Z |
| format | Article |
| id | doaj.art-47253286b9364a7aa57820fc0d2f2673 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-04-12T19:47:20Z |
| publishDate | 2013-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-47253286b9364a7aa57820fc0d2f26732022-12-22T03:18:55ZengDove Medical PressDrug Design, Development and Therapy1177-88812013-09-012013default10351041Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation proceduresIannitti TRottigni VPalmieri BT Iannitti,1,2 V Rottigni,2,3 B Palmieri2,31School of Biomedical Sciences, University of Leeds, Leeds, UK; 2Poliambulatorio del Secondo Parere, Modena, Italy; 3Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, ItalyBackground and aim: The use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil®) to manage facial swelling, edema, inflammation, ecchymosis, and hematoma, when applied immediately after a facial rejuvenation procedure.Materials and methods: We applied the plaster to the skin of 20 healthy patients for 12 hours immediately after hyaluronic acid-based procedure performed with the aim of erasing facial wrinkles of perioral and nasolabial folds and improving chin and eye contour. A further 20 patients underwent the same cosmetic procedure, but they were treated with an aescin 10% cream (applied immediately after the procedure, in the evening, and the morning after) and served as control group.Results: Betesil® application resulted in a significant improvement in swelling/edema/inflammation score, if compared with aescin 10% cream (P < 0.01). As for facial ecchymosis and hematoma around the needle injection track, only two patients in the active treatment group displayed minimal ecchymosis and hematoma. In the control group, two patients presented minimal ecchymosis and three slight hematoma. However, using the ecchymosis/hematoma score, no significant difference between Betesil® and aescin 10% cream groups was observed. Patients’ satisfaction was significantly higher among subjects receiving Betesil®, if compared to patients receiving aescin 10% cream (P < 0.01).Conclusion: The present study supports the use of Betesil® plaster immediately after facial cosmetic procedures in order to safely control swelling, edema, and inflammation.Keywords: aesthetic medicine, transdermal therapeutic system, betamethasone valerate, hyaluronic acidhttp://www.dovepress.com/corticosteroid-transdermal-delivery-to-target-swelling-edema-and-infla-a14494 |
| spellingShingle | Iannitti T Rottigni V Palmieri B Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures Drug Design, Development and Therapy |
| title | Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures |
| title_full | Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures |
| title_fullStr | Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures |
| title_full_unstemmed | Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures |
| title_short | Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures |
| title_sort | corticosteroid transdermal delivery to target swelling edema and inflammation following facial rejuvenation procedures |
| url | http://www.dovepress.com/corticosteroid-transdermal-delivery-to-target-swelling-edema-and-infla-a14494 |
| work_keys_str_mv | AT iannittit corticosteroidtransdermaldeliverytotargetswellingedemaandinflammationfollowingfacialrejuvenationprocedures AT rottigniv corticosteroidtransdermaldeliverytotargetswellingedemaandinflammationfollowingfacialrejuvenationprocedures AT palmierib corticosteroidtransdermaldeliverytotargetswellingedemaandinflammationfollowingfacialrejuvenationprocedures |