The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis
Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were...
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MDPI AG
2018-10-01
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| Series: | Nutrients |
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| Online Access: | http://www.mdpi.com/2072-6643/10/10/1395 |
| _version_ | 1811233487867346944 |
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| author | Qi Gao Tingyan Kou Bin Zhuang Yangyang Ren Xue Dong Qiuzhen Wang |
| author_facet | Qi Gao Tingyan Kou Bin Zhuang Yangyang Ren Xue Dong Qiuzhen Wang |
| author_sort | Qi Gao |
| collection | DOAJ |
| description | Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association. |
| first_indexed | 2024-04-12T11:20:51Z |
| format | Article |
| id | doaj.art-4725699fba1d40149649bf8eb73a685c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-12T11:20:51Z |
| publishDate | 2018-10-01 |
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| series | Nutrients |
| spelling | doaj.art-4725699fba1d40149649bf8eb73a685c2022-12-22T03:35:22ZengMDPI AGNutrients2072-66432018-10-011010139510.3390/nu10101395nu10101395The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-AnalysisQi Gao0Tingyan Kou1Bin Zhuang2Yangyang Ren3Xue Dong4Qiuzhen Wang5Department of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, ChinaDepartment of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, ChinaDepartment of the medical college of Qingdao University, Qingdao 266021, ChinaDepartment of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, ChinaDepartment of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, ChinaDepartment of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, ChinaEpidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.http://www.mdpi.com/2072-6643/10/10/1395vitamin Dserum 25(OH)Dsleepsleep qualitysleep durationsleep disorders |
| spellingShingle | Qi Gao Tingyan Kou Bin Zhuang Yangyang Ren Xue Dong Qiuzhen Wang The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis Nutrients vitamin D serum 25(OH)D sleep sleep quality sleep duration sleep disorders |
| title | The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis |
| title_full | The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis |
| title_fullStr | The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis |
| title_short | The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis |
| title_sort | association between vitamin d deficiency and sleep disorders a systematic review and meta analysis |
| topic | vitamin D serum 25(OH)D sleep sleep quality sleep duration sleep disorders |
| url | http://www.mdpi.com/2072-6643/10/10/1395 |
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