Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort Study
Chronic kidney disease (CKD) is significantly associated with lung cancer incidence. The aim of this study was to elucidate whether influenza vaccination reduces the incidence of lung cancer in patients with CKD. This cohort study enrolled patients with a record of CKD diagnosis from 2000 to 2012 in...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2072-6694/14/12/2926 |
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| author | Chun-Chao Chen Chia-Hsien Wu Cheng-Hsin Lin Chun-Chih Chiu Tsung-Yeh Yang Meng-Huan Lei Hsien-Tang Yeh William Jian Yu-Ann Fang Wen-Rui Hao Ju-Chi Liu |
| author_facet | Chun-Chao Chen Chia-Hsien Wu Cheng-Hsin Lin Chun-Chih Chiu Tsung-Yeh Yang Meng-Huan Lei Hsien-Tang Yeh William Jian Yu-Ann Fang Wen-Rui Hao Ju-Chi Liu |
| author_sort | Chun-Chao Chen |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is significantly associated with lung cancer incidence. The aim of this study was to elucidate whether influenza vaccination reduces the incidence of lung cancer in patients with CKD. This cohort study enrolled patients with a record of CKD diagnosis from 2000 to 2012 in Taiwan’s National Health Insurance Research Database. Included patients were divided into vaccinated and unvaccinated groups. In total 12,985 patients with CKD were enrolled. Among these patients, 5495 were vaccinated and 7490 were unvaccinated. The risk of lung cancer was significantly lower in the influenza vaccination group after adjusting for age, sex, dialysis status, lung diseases, comorbidities, level of urbanization, and monthly income (adjusted hazard ratio (HR): 0.50, 95% confidence interval (CI; 0.38–0.65), <i>p</i> < 0.05). Lower risk of lung cancer was observed in both sexes, all age groups, dialysis status and co-existed lung diseases. The association between the risk of lung cancer and vaccination appeared to be dose-dependent (adjusted HRs: 0.91 (0.66–1.25), 0.49 (0.34–0.71), and 0.25 (0.17–0.38) for patients who received 1, 2 or 3, and ≥4 vaccinations during the follow-up period, respectively). In conclusion, Influenza vaccination decreased the risk of lung cancer in patients diagnosed with CKD. This potentially protective effect against lung cancer appeared to be dose dependent. |
| first_indexed | 2024-03-10T00:12:57Z |
| format | Article |
| id | doaj.art-47279a6a5f014f8bb1f3f894e774df43 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:12:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-47279a6a5f014f8bb1f3f894e774df432023-11-23T15:56:33ZengMDPI AGCancers2072-66942022-06-011412292610.3390/cancers14122926Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort StudyChun-Chao Chen0Chia-Hsien Wu1Cheng-Hsin Lin2Chun-Chih Chiu3Tsung-Yeh Yang4Meng-Huan Lei5Hsien-Tang Yeh6William Jian7Yu-Ann Fang8Wen-Rui Hao9Ju-Chi Liu10Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei 110, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanCardiovascular Center, Lo-Hsu Medical Foundation Luodong Poh-Ai Hospital, Yilan 265, TaiwanDepartment of Surgery, Lotung Poh-Ai Hospital, Luodong 265, TaiwanDepartment of Emergency Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USADivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanChronic kidney disease (CKD) is significantly associated with lung cancer incidence. The aim of this study was to elucidate whether influenza vaccination reduces the incidence of lung cancer in patients with CKD. This cohort study enrolled patients with a record of CKD diagnosis from 2000 to 2012 in Taiwan’s National Health Insurance Research Database. Included patients were divided into vaccinated and unvaccinated groups. In total 12,985 patients with CKD were enrolled. Among these patients, 5495 were vaccinated and 7490 were unvaccinated. The risk of lung cancer was significantly lower in the influenza vaccination group after adjusting for age, sex, dialysis status, lung diseases, comorbidities, level of urbanization, and monthly income (adjusted hazard ratio (HR): 0.50, 95% confidence interval (CI; 0.38–0.65), <i>p</i> < 0.05). Lower risk of lung cancer was observed in both sexes, all age groups, dialysis status and co-existed lung diseases. The association between the risk of lung cancer and vaccination appeared to be dose-dependent (adjusted HRs: 0.91 (0.66–1.25), 0.49 (0.34–0.71), and 0.25 (0.17–0.38) for patients who received 1, 2 or 3, and ≥4 vaccinations during the follow-up period, respectively). In conclusion, Influenza vaccination decreased the risk of lung cancer in patients diagnosed with CKD. This potentially protective effect against lung cancer appeared to be dose dependent.https://www.mdpi.com/2072-6694/14/12/2926chronic kidney diseaseinfluenza vaccinationlung cancer |
| spellingShingle | Chun-Chao Chen Chia-Hsien Wu Cheng-Hsin Lin Chun-Chih Chiu Tsung-Yeh Yang Meng-Huan Lei Hsien-Tang Yeh William Jian Yu-Ann Fang Wen-Rui Hao Ju-Chi Liu Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort Study Cancers chronic kidney disease influenza vaccination lung cancer |
| title | Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort Study |
| title_full | Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort Study |
| title_fullStr | Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort Study |
| title_full_unstemmed | Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort Study |
| title_short | Influenza Vaccination and Risk of Lung Cancer in Patients with Chronic Kidney Disease: A Nationwide, Population-Based Cohort Study |
| title_sort | influenza vaccination and risk of lung cancer in patients with chronic kidney disease a nationwide population based cohort study |
| topic | chronic kidney disease influenza vaccination lung cancer |
| url | https://www.mdpi.com/2072-6694/14/12/2926 |
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