N-cadherin, spine dynamics, and synaptic function
Dendritic spines are one half (the postsynaptic half) of most excitatory synapses. Ever since the direct observation over a decade ago that spines can continually change size and shape, spine dynamics has been of great research interest, especially as a mechanism for structural synaptic plasticity....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2008-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.01.035.2008/full |
| _version_ | 1811342050495299584 |
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| author | Shreesh P Mysore Chin-Yin Tai Erin M Schuman |
| author_facet | Shreesh P Mysore Chin-Yin Tai Erin M Schuman |
| author_sort | Shreesh P Mysore |
| collection | DOAJ |
| description | Dendritic spines are one half (the postsynaptic half) of most excitatory synapses. Ever since the direct observation over a decade ago that spines can continually change size and shape, spine dynamics has been of great research interest, especially as a mechanism for structural synaptic plasticity. In concert with this ongoing spine dynamics, the stability of the synapse is also needed to allow continued, reliable synaptic communication. Various cell-adhesion molecules help to structurally stabilize a synapse and its proteins. Here, we review the effects of disrupting N-cadherin, a prominent trans-synaptic adhesion molecule, on spine dynamics, as reported in Mysore et al., (2007). We highlight the novel method adopted therein to reliably detect even subtle changes in fast and slow spine dynamics. We summarize the structural, functional, and molecular consequences of acute N-cadherin disruption, and tie them in, in a working model, with longer-term effects on spines and synapses reported in the literature. |
| first_indexed | 2024-04-13T19:04:41Z |
| format | Article |
| id | doaj.art-4728f9e0cf45497d8a43b8aff0c15446 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T19:04:41Z |
| publishDate | 2008-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-4728f9e0cf45497d8a43b8aff0c154462022-12-22T02:34:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2008-12-01210.3389/neuro.01.035.2008392N-cadherin, spine dynamics, and synaptic functionShreesh P Mysore0Chin-Yin Tai1Erin M Schuman2Stanford UniversityCaltechCaltechDendritic spines are one half (the postsynaptic half) of most excitatory synapses. Ever since the direct observation over a decade ago that spines can continually change size and shape, spine dynamics has been of great research interest, especially as a mechanism for structural synaptic plasticity. In concert with this ongoing spine dynamics, the stability of the synapse is also needed to allow continued, reliable synaptic communication. Various cell-adhesion molecules help to structurally stabilize a synapse and its proteins. Here, we review the effects of disrupting N-cadherin, a prominent trans-synaptic adhesion molecule, on spine dynamics, as reported in Mysore et al., (2007). We highlight the novel method adopted therein to reliably detect even subtle changes in fast and slow spine dynamics. We summarize the structural, functional, and molecular consequences of acute N-cadherin disruption, and tie them in, in a working model, with longer-term effects on spines and synapses reported in the literature.http://journal.frontiersin.org/Journal/10.3389/neuro.01.035.2008/fullHippocampusMeasurement noisemotilityN-cadherinspine dynamicsstructural constraints |
| spellingShingle | Shreesh P Mysore Chin-Yin Tai Erin M Schuman N-cadherin, spine dynamics, and synaptic function Frontiers in Neuroscience Hippocampus Measurement noise motility N-cadherin spine dynamics structural constraints |
| title | N-cadherin, spine dynamics, and synaptic function |
| title_full | N-cadherin, spine dynamics, and synaptic function |
| title_fullStr | N-cadherin, spine dynamics, and synaptic function |
| title_full_unstemmed | N-cadherin, spine dynamics, and synaptic function |
| title_short | N-cadherin, spine dynamics, and synaptic function |
| title_sort | n cadherin spine dynamics and synaptic function |
| topic | Hippocampus Measurement noise motility N-cadherin spine dynamics structural constraints |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.01.035.2008/full |
| work_keys_str_mv | AT shreeshpmysore ncadherinspinedynamicsandsynapticfunction AT chinyintai ncadherinspinedynamicsandsynapticfunction AT erinmschuman ncadherinspinedynamicsandsynapticfunction |