Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study)
Background: Benign prostatic hyperplasia and prostatic adenocarcinoma are two of the most common pathologic mass lesions. Both are encountered mainly in elderly males. The caspases family is a group of at least 15 known proteases that serve as initiator & effector molecules of the apoptosis path...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2009-10-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1134 |
| _version_ | 1797368863596216320 |
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| author | Alaa A. Qader Nabeel W. Rasheed |
| author_facet | Alaa A. Qader Nabeel W. Rasheed |
| author_sort | Alaa A. Qader |
| collection | DOAJ |
| description | Background: Benign prostatic hyperplasia and prostatic adenocarcinoma are two of the most common pathologic mass lesions. Both are encountered mainly in elderly males. The caspases family is a group of at least 15 known proteases that serve as initiator & effector molecules of the apoptosis pathway. Caspase-3, in particular, is thought to play a pathogenetic role in both prostatic hyperplasia and carcinoma. Finasteride is a medication that has routinely been given to patients with hyperplasia and carcinoma; its prostate size-reducing effect is thought to be mediated through caspases.
Patients and methods: fifty patients with prostatic mass lesions were included in this study (20 with hyperplasia & 30 with adenocarcinoma); all were on finasteride treatment. The carcinoma cases were graded according to Gleason scoring system. All cases were analyzed for procaspase-3 strength of staining.
Results: benign hyperplasia & well-differentiated carcinomas show high expression of procaspase-3, in contrast loss of expression of this marker was noted in moderately & poorly differentiated carcinomas.
Conclusion: there is a strong statistical correlation between caspase-3 expression and the degree of tumor differentiation. This may allow the utilization of this marker as a potential prognostic factor, especially in limited biopsy samples. |
| first_indexed | 2024-03-08T17:38:48Z |
| format | Article |
| id | doaj.art-472929f4939843f7b373541cf113dc7c |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:38:48Z |
| publishDate | 2009-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-472929f4939843f7b373541cf113dc7c2024-01-02T11:25:02ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572009-10-0151310.32007/jfacmedbagdad.v3316-319%Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study)Alaa A. Qader0Nabeel W. Rasheed1Dept. of Pathology, Al-Anbar Faculty of MedicineDept. of Pathology, Baghdad Faculty of MedicineBackground: Benign prostatic hyperplasia and prostatic adenocarcinoma are two of the most common pathologic mass lesions. Both are encountered mainly in elderly males. The caspases family is a group of at least 15 known proteases that serve as initiator & effector molecules of the apoptosis pathway. Caspase-3, in particular, is thought to play a pathogenetic role in both prostatic hyperplasia and carcinoma. Finasteride is a medication that has routinely been given to patients with hyperplasia and carcinoma; its prostate size-reducing effect is thought to be mediated through caspases. Patients and methods: fifty patients with prostatic mass lesions were included in this study (20 with hyperplasia & 30 with adenocarcinoma); all were on finasteride treatment. The carcinoma cases were graded according to Gleason scoring system. All cases were analyzed for procaspase-3 strength of staining. Results: benign hyperplasia & well-differentiated carcinomas show high expression of procaspase-3, in contrast loss of expression of this marker was noted in moderately & poorly differentiated carcinomas. Conclusion: there is a strong statistical correlation between caspase-3 expression and the degree of tumor differentiation. This may allow the utilization of this marker as a potential prognostic factor, especially in limited biopsy samples.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1134prostatic hyperplasia, prostatic adenocarcinoma, procaspase-3, Gleason grade |
| spellingShingle | Alaa A. Qader Nabeel W. Rasheed Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study) مجلة كلية الطب prostatic hyperplasia, prostatic adenocarcinoma, procaspase-3, Gleason grade |
| title | Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study) |
| title_full | Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study) |
| title_fullStr | Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study) |
| title_full_unstemmed | Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study) |
| title_short | Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study) |
| title_sort | procaspase 3 status in benign prostatic hyperplasia and carcinoma a correlative retrospective study |
| topic | prostatic hyperplasia, prostatic adenocarcinoma, procaspase-3, Gleason grade |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1134 |
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