High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm
Purpose: Atrial fibrillation (AF) is associated with an increased risk for cardiovascular morbidity and mortality, not entirely explained by thromboembolism. The underlying mechanisms for this association are largely unknown. Similarly, high blood pressure (BP) increases the risk for cardiovascular...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-09-01
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| Series: | Blood Pressure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08037051.2018.1436400 |
| _version_ | 1797685069519781888 |
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| author | Joakim Olbers Adam Gille Petter Ljungman Mårten Rosenqvist Jan Östergren Nils Witt |
| author_facet | Joakim Olbers Adam Gille Petter Ljungman Mårten Rosenqvist Jan Östergren Nils Witt |
| author_sort | Joakim Olbers |
| collection | DOAJ |
| description | Purpose: Atrial fibrillation (AF) is associated with an increased risk for cardiovascular morbidity and mortality, not entirely explained by thromboembolism. The underlying mechanisms for this association are largely unknown. Similarly, high blood pressure (BP) increases the risk for cardiovascular events. Despite this the interplay between AF and BP is insufficiently studied. The purpose of this study was to examine and quantify the beat-to-beat blood pressure variability in patients with AF in comparison to a control group of patients with sinus rhythm. Materials and methods: We studied 33 patients - 21 in atrial fibrillation and 12 in sinus rhythm - undergoing routine coronary angiography. Invasive blood pressure was recorded at three locations: radial artery, brachial artery and ascending aorta. Blood pressure variability, defined as average beat-to-beat blood pressure difference, was calculated for systolic and diastolic blood pressure at each site. Results: We observed a significant difference (p < .001) in systolic and diastolic blood pressure variability between the atrial fibrillation and sinus rhythm groups at all locations. Systolic blood pressure variability roughly doubled in the atrial fibrillation group compared to the sinus rhythm group (4.9 and 2.4 mmHg respectively). Diastolic beat-to-beat blood pressure variability was approximately 6 times as high in the atrial fibrillation group compared to the sinus rhythm group (7.5 and 1.2 mmHg respectively). No significant difference in blood pressure variability was seen between measurement locations. Conclusions: Beat-to-beat blood pressure variability in patients with atrial fibrillation was substantially higher than in patients with sinus rhythm. Hemodynamic effects of this beat-to-beat variation in blood pressure may negatively affect vascular structure and function, which may contribute to the increased cardiovascular morbidity and mortality seen in patients with atrial fibrillation. |
| first_indexed | 2024-03-12T00:40:08Z |
| format | Article |
| id | doaj.art-472b137cfb4842e6ba2401f3ac78f26d |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:40:08Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-472b137cfb4842e6ba2401f3ac78f26d2023-09-15T08:45:22ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992018-09-0127524925510.1080/08037051.2018.14364001436400High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythmJoakim Olbers0Adam Gille1Petter Ljungman2Mårten Rosenqvist3Jan Östergren4Nils Witt5Södersjukhuset, Karolinska InstitutetSödersjukhuset, Karolinska InstitutetKarolinska Institutet, Danderyd University HospitalKarolinska Institutet, Danderyd University HospitalKarolinska University Hospital, Karolinska InstitutetSödersjukhuset, Karolinska InstitutetPurpose: Atrial fibrillation (AF) is associated with an increased risk for cardiovascular morbidity and mortality, not entirely explained by thromboembolism. The underlying mechanisms for this association are largely unknown. Similarly, high blood pressure (BP) increases the risk for cardiovascular events. Despite this the interplay between AF and BP is insufficiently studied. The purpose of this study was to examine and quantify the beat-to-beat blood pressure variability in patients with AF in comparison to a control group of patients with sinus rhythm. Materials and methods: We studied 33 patients - 21 in atrial fibrillation and 12 in sinus rhythm - undergoing routine coronary angiography. Invasive blood pressure was recorded at three locations: radial artery, brachial artery and ascending aorta. Blood pressure variability, defined as average beat-to-beat blood pressure difference, was calculated for systolic and diastolic blood pressure at each site. Results: We observed a significant difference (p < .001) in systolic and diastolic blood pressure variability between the atrial fibrillation and sinus rhythm groups at all locations. Systolic blood pressure variability roughly doubled in the atrial fibrillation group compared to the sinus rhythm group (4.9 and 2.4 mmHg respectively). Diastolic beat-to-beat blood pressure variability was approximately 6 times as high in the atrial fibrillation group compared to the sinus rhythm group (7.5 and 1.2 mmHg respectively). No significant difference in blood pressure variability was seen between measurement locations. Conclusions: Beat-to-beat blood pressure variability in patients with atrial fibrillation was substantially higher than in patients with sinus rhythm. Hemodynamic effects of this beat-to-beat variation in blood pressure may negatively affect vascular structure and function, which may contribute to the increased cardiovascular morbidity and mortality seen in patients with atrial fibrillation.http://dx.doi.org/10.1080/08037051.2018.1436400atrial fibrillationhemodynamicsblood pressureblood pressure measurement/monitoringatherosclerosisblood pressure variability |
| spellingShingle | Joakim Olbers Adam Gille Petter Ljungman Mårten Rosenqvist Jan Östergren Nils Witt High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm Blood Pressure atrial fibrillation hemodynamics blood pressure blood pressure measurement/monitoring atherosclerosis blood pressure variability |
| title | High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm |
| title_full | High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm |
| title_fullStr | High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm |
| title_full_unstemmed | High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm |
| title_short | High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm |
| title_sort | high beat to beat blood pressure variability in atrial fibrillation compared to sinus rhythm |
| topic | atrial fibrillation hemodynamics blood pressure blood pressure measurement/monitoring atherosclerosis blood pressure variability |
| url | http://dx.doi.org/10.1080/08037051.2018.1436400 |
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