Innate Lymphoid Cells and Their Role in the Immune Response to Infections
Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells th...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/13/4/335 |
| _version_ | 1797298611765116928 |
|---|---|
| author | Marek Fol Wojciech Karpik Agnieszka Zablotni Jakub Kulesza Ewelina Kulesza Magdalena Godkowicz Magdalena Druszczynska |
| author_facet | Marek Fol Wojciech Karpik Agnieszka Zablotni Jakub Kulesza Ewelina Kulesza Magdalena Godkowicz Magdalena Druszczynska |
| author_sort | Marek Fol |
| collection | DOAJ |
| description | Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells that act as tissue-resident sentinels against infections. Numerous studies have elucidated the characteristics of ILC subgroups, but the mechanisms controlling protective or pathological responses to pathogens still need to be better understood. This review summarizes the functions of ILCs in the immunology of infections caused by different intracellular and extracellular pathogens and discusses their possible therapeutic potential. |
| first_indexed | 2024-03-07T22:37:31Z |
| format | Article |
| id | doaj.art-472b71def6fc4744842300a6e5c3bf52 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-07T22:37:31Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-472b71def6fc4744842300a6e5c3bf522024-02-23T15:11:55ZengMDPI AGCells2073-44092024-02-0113433510.3390/cells13040335Innate Lymphoid Cells and Their Role in the Immune Response to InfectionsMarek Fol0Wojciech Karpik1Agnieszka Zablotni2Jakub Kulesza3Ewelina Kulesza4Magdalena Godkowicz5Magdalena Druszczynska6Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, PolandDepartment of Bacterial Biology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, PolandDepartment of Internal Diseases and Clinical Pharmacology, Medical University of Lodz, 91-347 Lodz, PolandDepartment of Rheumatology and Internal Diseases, Medical University of Lodz, 90-549 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, PolandOver the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells that act as tissue-resident sentinels against infections. Numerous studies have elucidated the characteristics of ILC subgroups, but the mechanisms controlling protective or pathological responses to pathogens still need to be better understood. This review summarizes the functions of ILCs in the immunology of infections caused by different intracellular and extracellular pathogens and discusses their possible therapeutic potential.https://www.mdpi.com/2073-4409/13/4/335innate immune cells (ILC)intracellular pathogensextracellular pathogens |
| spellingShingle | Marek Fol Wojciech Karpik Agnieszka Zablotni Jakub Kulesza Ewelina Kulesza Magdalena Godkowicz Magdalena Druszczynska Innate Lymphoid Cells and Their Role in the Immune Response to Infections Cells innate immune cells (ILC) intracellular pathogens extracellular pathogens |
| title | Innate Lymphoid Cells and Their Role in the Immune Response to Infections |
| title_full | Innate Lymphoid Cells and Their Role in the Immune Response to Infections |
| title_fullStr | Innate Lymphoid Cells and Their Role in the Immune Response to Infections |
| title_full_unstemmed | Innate Lymphoid Cells and Their Role in the Immune Response to Infections |
| title_short | Innate Lymphoid Cells and Their Role in the Immune Response to Infections |
| title_sort | innate lymphoid cells and their role in the immune response to infections |
| topic | innate immune cells (ILC) intracellular pathogens extracellular pathogens |
| url | https://www.mdpi.com/2073-4409/13/4/335 |
| work_keys_str_mv | AT marekfol innatelymphoidcellsandtheirroleintheimmuneresponsetoinfections AT wojciechkarpik innatelymphoidcellsandtheirroleintheimmuneresponsetoinfections AT agnieszkazablotni innatelymphoidcellsandtheirroleintheimmuneresponsetoinfections AT jakubkulesza innatelymphoidcellsandtheirroleintheimmuneresponsetoinfections AT ewelinakulesza innatelymphoidcellsandtheirroleintheimmuneresponsetoinfections AT magdalenagodkowicz innatelymphoidcellsandtheirroleintheimmuneresponsetoinfections AT magdalenadruszczynska innatelymphoidcellsandtheirroleintheimmuneresponsetoinfections |