Metabolic alterations precede neurofilament changes in presymptomatic ALS gene carriersResearch in context

Metabolic alterations precede neurofilament changes in presymptomatic ALS gene carriersResearch in context

Summary: Background: The emergence of potentially effective new therapies for genetic forms of amyotrophic lateral sclerosis (ALS) necessitates the identification of biomarkers to facilitate early treatment, prior to the onset of motor symptoms. Here, we sought to investigate whether metabolic alte...

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Main Authors: Johannes Dorst, Patrick Weydt, David Brenner, Simon Witzel, Katharina Kandler, André Huss, Christine Herrmann, Maximilian Wiesenfarth, Antje Knehr, Kornelia Günther, Kathrin Müller, Jochen H. Weishaupt, Johannes Prudlo, Karin Forsberg, Peter M. Andersen, Angela Rosenbohm, Joachim Schuster, Francesco Roselli, Luc Dupuis, Benjamin Mayer, Hayrettin Tumani, Jan Kassubek, Albert C. Ludolph
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:EBioMedicine
Subjects:
Amyotrophic lateral sclerosis
Presymptomatic
Mutations carriers
Metabolism
Metabolic
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423000865

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