Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells
Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy for tumor tissue, which kills tumor cells with neutron capture reaction. Boron neutron capture therapy has become a technical means for glioma, melanoma, and other diseases has been included in the clinical backup program. Howeve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1105472/full |
| _version_ | 1811168276639645696 |
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| author | Song Wang Song Wang Zhengchao Zhang Zhengchao Zhang Lele Miao Lele Miao Jiaxing Zhang Jiaxing Zhang Futian Tang Futian Tang Muzhou Teng Muzhou Teng Yumin Li Yumin Li |
| author_facet | Song Wang Song Wang Zhengchao Zhang Zhengchao Zhang Lele Miao Lele Miao Jiaxing Zhang Jiaxing Zhang Futian Tang Futian Tang Muzhou Teng Muzhou Teng Yumin Li Yumin Li |
| author_sort | Song Wang |
| collection | DOAJ |
| description | Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy for tumor tissue, which kills tumor cells with neutron capture reaction. Boron neutron capture therapy has become a technical means for glioma, melanoma, and other diseases has been included in the clinical backup program. However, BNCT is faced with the key problem of developing and innovating more efficient boron delivery agents to solve the targeting and selectivity. We constructed a tyrosine kinase inhibitor-L-p-boronophenylalanine (TKI-BPA) molecule, aiming to improve the selectivity of boron delivery agents by conjugating targeted drugs while increasing the molecular solubility by adding hydrophilic groups. It shows excellent selectivity in differential uptake of cells, and its solubility is more than 6 times higher than BPA, leading to the saving of boron delivery agents. This modification method is effective for improving the efficiency of the boron delivery agent and is expected to become a potential alternative with high clinical application value. |
| first_indexed | 2024-04-10T16:23:25Z |
| format | Article |
| id | doaj.art-472c43af4fa24619864d24af68819eac |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T16:23:25Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-472c43af4fa24619864d24af68819eac2023-02-09T10:00:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.11054721105472Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cellsSong Wang0Song Wang1Zhengchao Zhang2Zhengchao Zhang3Lele Miao4Lele Miao5Jiaxing Zhang6Jiaxing Zhang7Futian Tang8Futian Tang9Muzhou Teng10Muzhou Teng11Yumin Li12Yumin Li13Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaBoron Neutron Capture Therapy (BNCT) is a new binary radiation therapy for tumor tissue, which kills tumor cells with neutron capture reaction. Boron neutron capture therapy has become a technical means for glioma, melanoma, and other diseases has been included in the clinical backup program. However, BNCT is faced with the key problem of developing and innovating more efficient boron delivery agents to solve the targeting and selectivity. We constructed a tyrosine kinase inhibitor-L-p-boronophenylalanine (TKI-BPA) molecule, aiming to improve the selectivity of boron delivery agents by conjugating targeted drugs while increasing the molecular solubility by adding hydrophilic groups. It shows excellent selectivity in differential uptake of cells, and its solubility is more than 6 times higher than BPA, leading to the saving of boron delivery agents. This modification method is effective for improving the efficiency of the boron delivery agent and is expected to become a potential alternative with high clinical application value.https://www.frontiersin.org/articles/10.3389/fonc.2023.1105472/fullboron neutron capture therapy (BNCT)boron delivery agenttumorselectivitysolubility |
| spellingShingle | Song Wang Song Wang Zhengchao Zhang Zhengchao Zhang Lele Miao Lele Miao Jiaxing Zhang Jiaxing Zhang Futian Tang Futian Tang Muzhou Teng Muzhou Teng Yumin Li Yumin Li Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells Frontiers in Oncology boron neutron capture therapy (BNCT) boron delivery agent tumor selectivity solubility |
| title | Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells |
| title_full | Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells |
| title_fullStr | Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells |
| title_full_unstemmed | Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells |
| title_short | Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells |
| title_sort | construction of targeted 10b delivery agents and their uptake in gastric and pancreatic cancer cells |
| topic | boron neutron capture therapy (BNCT) boron delivery agent tumor selectivity solubility |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1105472/full |
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