Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity

Summary: Adequate alternatives to conventional animal testing are needed to study developmental neurotoxicity (DNT). Here, we used kinematic analysis to assess DNT of known (toluene (TOL) and chlorpyrifos (CPS)) and putative (β-N-methylamino-L-alanine (BMAA)) neurotoxic compounds. Drosophila melanog...

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Bibliographic Details
Main Authors: Ana Cabrita, Alexandra M. Medeiros, Telmo Pereira, António Sebastião Rodrigues, Michel Kranendonk, César S. Mendes
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008136

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