ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORS
The regularities of quick (5 sec) incorporation of exogenous [14C]arachidonic acid (AA) into the various fractions of phospholipids (PL) and neutral lipids (NL) and it’s long-term (60 min) interfractional conversions in crude mononuclear cells (MNC) isolated from the peripheral blood of patients wit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Scientia Publishing House
2017-11-01
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| Series: | Juvenis Scientia |
| Subjects: | |
| Online Access: | https://jscientia.org/index.php/js/article/view/78 |
| _version_ | 1819094380018925568 |
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| author | G. V. Hakobyan T. R. Torgomyan M. P. Lazyan K. H. Harutyunyan T. B. Batikyan K. A. Alexanyan Yu. V. Tadevosyan |
| author_facet | G. V. Hakobyan T. R. Torgomyan M. P. Lazyan K. H. Harutyunyan T. B. Batikyan K. A. Alexanyan Yu. V. Tadevosyan |
| author_sort | G. V. Hakobyan |
| collection | DOAJ |
| description | The regularities of quick (5 sec) incorporation of exogenous [14C]arachidonic acid (AA) into the various fractions of phospholipids (PL) and neutral lipids (NL) and it’s long-term (60 min) interfractional conversions in crude mononuclear cells (MNC) isolated from the peripheral blood of patients with breast (BC) and ovarian (OC) cancers in comparison with the healthy people was examined in the article.
The data obtained provide evidence for reliable and identical disturbances in the MNC membrane lipids quick as well as long-term AA-modification mechanisms in BC and OC.
We concluded that in the peripheral blood MNC some of the mechanisms responsible for fatty acid-content modification of lipids by AA are involved in the pathogenesis of BC and OC. |
| first_indexed | 2024-12-21T23:26:29Z |
| format | Article |
| id | doaj.art-472e7daf46b1486790d1cfa559f90b02 |
| institution | Directory Open Access Journal |
| issn | 2414-3782 2414-3790 |
| language | English |
| last_indexed | 2024-12-21T23:26:29Z |
| publishDate | 2017-11-01 |
| publisher | Scientia Publishing House |
| record_format | Article |
| series | Juvenis Scientia |
| spelling | doaj.art-472e7daf46b1486790d1cfa559f90b022022-12-21T18:46:37ZengScientia Publishing HouseJuvenis Scientia2414-37822414-37902017-11-01112225ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORSG. V. Hakobyan0T. R. Torgomyan1M. P. Lazyan2K. H. Harutyunyan3T. B. Batikyan4K. A. Alexanyan5Yu. V. Tadevosyan6Institute of Molecular Biology, NAS RAInstitute of Molecular Biology, NAS RAInstitute of Molecular Biology, NAS RAInstitute of Molecular Biology, NAS RAInstitute of Molecular Biology, NAS RACenter of Oncology after V. Fanarjyan, MH RAInstitute of Molecular Biology, NAS RAThe regularities of quick (5 sec) incorporation of exogenous [14C]arachidonic acid (AA) into the various fractions of phospholipids (PL) and neutral lipids (NL) and it’s long-term (60 min) interfractional conversions in crude mononuclear cells (MNC) isolated from the peripheral blood of patients with breast (BC) and ovarian (OC) cancers in comparison with the healthy people was examined in the article. The data obtained provide evidence for reliable and identical disturbances in the MNC membrane lipids quick as well as long-term AA-modification mechanisms in BC and OC. We concluded that in the peripheral blood MNC some of the mechanisms responsible for fatty acid-content modification of lipids by AA are involved in the pathogenesis of BC and OC.https://jscientia.org/index.php/js/article/view/78mononuclear cellslipidsarachidonic acidbreast cancerovarian cancer |
| spellingShingle | G. V. Hakobyan T. R. Torgomyan M. P. Lazyan K. H. Harutyunyan T. B. Batikyan K. A. Alexanyan Yu. V. Tadevosyan ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORS Juvenis Scientia mononuclear cells lipids arachidonic acid breast cancer ovarian cancer |
| title | ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORS |
| title_full | ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORS |
| title_fullStr | ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORS |
| title_full_unstemmed | ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORS |
| title_short | ARACHIDONIL-LIPIDS OF BLOOD MONONUCLEAR CELLS AS A BIOMARKER FOR EARLY DETECTION OF DIFFERENT TUMORS |
| title_sort | arachidonil lipids of blood mononuclear cells as a biomarker for early detection of different tumors |
| topic | mononuclear cells lipids arachidonic acid breast cancer ovarian cancer |
| url | https://jscientia.org/index.php/js/article/view/78 |
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