Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant Recipients
<p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"&...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences
2005-05-01
|
| Series: | Urology Journal |
| Online Access: | http://www.urologyjournal.org/index.php/uj/article/view/274 |
| _version_ | 1819179929766461440 |
|---|---|
| author | Mahmoudreza Moradi Mohammadreza Abbasi As’ad Moradi Ali Boskabadi Amir Jalali |
| author_facet | Mahmoudreza Moradi Mohammadreza Abbasi As’ad Moradi Ali Boskabadi Amir Jalali |
| author_sort | Mahmoudreza Moradi |
| collection | DOAJ |
| description | <p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Purpose:</strong> Asymptomatic bacteriuria is a very common complication after kidney transplantation and the need for antibiotic therapy is controversial. The aim of this study was to evaluate the effect of antibiotic therapy on the clinical course of asymptomatic bacteriuria in renal transplant recipients.</span></span></p><p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Materials and Methods:</strong> In the present study, 88 kidney transplant recipients with asymptomatic bacteriuria were divided into two groups of cases and controls. The patients had been selected from among those with at least 1 year follow-up. In the case group, asymptomatic bacteriuric episodes were treated with antibiotics, and in control group, they were followed without antibiotic therapy. The follow-up period was 9 to 12 months. Bacteriuric episodes, symptomatic urinary tract infection (UTI) episodes, and changes in plasma creatinine level were recorded and compared between the two groups.</span></span></p><p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Results:</strong> The rate of bacteriuric episodes and symptomatic UTIs were not significantly different between the two groups (P > 0.05). In addition, level of plasma creatinine did not increase significantly in neither of the groups during the study (P > 0.05).</span></span></p><p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Conclusion:</strong> It seems that treatment of asymptomatic bacteriuria in kidney recipients does not decrease the rate of UTI episodes afterwards. Asymptomatic bacteriuria does not affect renal function in short term. Thus, we can abandon antibiotic therapy, subject to careful follow-up.</span></span></p> |
| first_indexed | 2024-12-22T22:06:15Z |
| format | Article |
| id | doaj.art-472eaa9903f54551a040c1ca00e12ec2 |
| institution | Directory Open Access Journal |
| issn | 1735-1308 1735-546X |
| language | English |
| last_indexed | 2024-12-22T22:06:15Z |
| publishDate | 2005-05-01 |
| publisher | Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Urology Journal |
| spelling | doaj.art-472eaa9903f54551a040c1ca00e12ec22022-12-21T18:10:58ZengUrology and Nephrology Research Center, Shahid Beheshti University of Medical SciencesUrology Journal1735-13081735-546X2005-05-01213235Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant RecipientsMahmoudreza MoradiMohammadreza AbbasiAs’ad MoradiAli BoskabadiAmir Jalali<p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Purpose:</strong> Asymptomatic bacteriuria is a very common complication after kidney transplantation and the need for antibiotic therapy is controversial. The aim of this study was to evaluate the effect of antibiotic therapy on the clinical course of asymptomatic bacteriuria in renal transplant recipients.</span></span></p><p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Materials and Methods:</strong> In the present study, 88 kidney transplant recipients with asymptomatic bacteriuria were divided into two groups of cases and controls. The patients had been selected from among those with at least 1 year follow-up. In the case group, asymptomatic bacteriuric episodes were treated with antibiotics, and in control group, they were followed without antibiotic therapy. The follow-up period was 9 to 12 months. Bacteriuric episodes, symptomatic urinary tract infection (UTI) episodes, and changes in plasma creatinine level were recorded and compared between the two groups.</span></span></p><p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Results:</strong> The rate of bacteriuric episodes and symptomatic UTIs were not significantly different between the two groups (P > 0.05). In addition, level of plasma creatinine did not increase significantly in neither of the groups during the study (P > 0.05).</span></span></p><p class="MsoNormal" style="text-justify: kashida; margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify; text-kashida: 0%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Conclusion:</strong> It seems that treatment of asymptomatic bacteriuria in kidney recipients does not decrease the rate of UTI episodes afterwards. Asymptomatic bacteriuria does not affect renal function in short term. Thus, we can abandon antibiotic therapy, subject to careful follow-up.</span></span></p>http://www.urologyjournal.org/index.php/uj/article/view/274 |
| spellingShingle | Mahmoudreza Moradi Mohammadreza Abbasi As’ad Moradi Ali Boskabadi Amir Jalali Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant Recipients Urology Journal |
| title | Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant Recipients |
| title_full | Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant Recipients |
| title_fullStr | Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant Recipients |
| title_full_unstemmed | Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant Recipients |
| title_short | Effect of Antibiotic Therapy on Asymptomatic Bacteriuria in Kidney Transplant Recipients |
| title_sort | effect of antibiotic therapy on asymptomatic bacteriuria in kidney transplant recipients |
| url | http://www.urologyjournal.org/index.php/uj/article/view/274 |
| work_keys_str_mv | AT mahmoudrezamoradi effectofantibiotictherapyonasymptomaticbacteriuriainkidneytransplantrecipients AT mohammadrezaabbasi effectofantibiotictherapyonasymptomaticbacteriuriainkidneytransplantrecipients AT asadmoradi effectofantibiotictherapyonasymptomaticbacteriuriainkidneytransplantrecipients AT aliboskabadi effectofantibiotictherapyonasymptomaticbacteriuriainkidneytransplantrecipients AT amirjalali effectofantibiotictherapyonasymptomaticbacteriuriainkidneytransplantrecipients |