REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION
The paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the study of their interaction with Hantavirus can be e...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/938 |
| _version_ | 1797237680994516992 |
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| author | N. G. Plekhova I. N. Lyapun L. M. Somova G. G. Kompanets I. N. Smirnov |
| author_facet | N. G. Plekhova I. N. Lyapun L. M. Somova G. G. Kompanets I. N. Smirnov |
| author_sort | N. G. Plekhova |
| collection | DOAJ |
| description | The paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the study of their interaction with Hantavirus can be extrapolated to monocytic cells of origin of mammals. It is indicated that Hantaviruses are resistant to the effects of monocytes/macrophages and are capable of intracellular replication in them breaking thus the biological barrier preventing the spread of the pathogen from the primary site of infection and protects against infected sensitive cells of various organs. With respect of neutrophils revealed that hantavirus showing cytopathogenic properties, as indicated by the appearance of apoptotic cells and modified periods of reduced viability of the cell culture. |
| first_indexed | 2024-03-08T12:22:59Z |
| format | Article |
| id | doaj.art-472fa3758da247bf8932a9915c8d0a13 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:36Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-472fa3758da247bf8932a9915c8d0a132024-03-28T07:49:04ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)297300884REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTIONN. G. Plekhova0I. N. Lyapun1L. M. Somova2G. G. Kompanets3I. N. Smirnov4Research Institute of Epidemiology and Microbiology SB RAMS; Far Eastern Federal UniversityResearch Institute of Epidemiology and Microbiology SB RAMSResearch Institute of Epidemiology and Microbiology SB RAMSResearch Institute of Epidemiology and Microbiology SB RAMSFar Eastern Federal UniversityThe paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the study of their interaction with Hantavirus can be extrapolated to monocytic cells of origin of mammals. It is indicated that Hantaviruses are resistant to the effects of monocytes/macrophages and are capable of intracellular replication in them breaking thus the biological barrier preventing the spread of the pathogen from the primary site of infection and protects against infected sensitive cells of various organs. With respect of neutrophils revealed that hantavirus showing cytopathogenic properties, as indicated by the appearance of apoptotic cells and modified periods of reduced viability of the cell culture.https://www.actabiomedica.ru/jour/article/view/938monocytesmacrophagesneutrophilsviral infectionultrastructuremetabolism of cell |
| spellingShingle | N. G. Plekhova I. N. Lyapun L. M. Somova G. G. Kompanets I. N. Smirnov REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION Acta Biomedica Scientifica monocytes macrophages neutrophils viral infection ultrastructure metabolism of cell |
| title | REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION |
| title_full | REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION |
| title_fullStr | REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION |
| title_full_unstemmed | REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION |
| title_short | REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION |
| title_sort | reactivity of cells innate immunity in the pathogenesis of hantaviral infection |
| topic | monocytes macrophages neutrophils viral infection ultrastructure metabolism of cell |
| url | https://www.actabiomedica.ru/jour/article/view/938 |
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