NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells

NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells

Development of resistance to therapy in ovarian cancer is a major hinderance for therapeutic efficacy; however, new mechanisms of the resistance remain to be elucidated. NADPH oxidase 4 (NOX4) is responsible for higher NADPH activity to increase reactive oxygen species (ROS) production. In this stud...

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Bibliographic Details
Main Authors: Wen-Jing Liu, Ying-Xue Huang, Wei Wang, Ye Zhang, Bing-Jie Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
NOX4
HIF-1α
HER3
therapeutic resistance
ovarian cancer
Online Access:https://www.mdpi.com/2073-4409/10/7/1647

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