Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled study
Abstract Background Improvement in cardiac function has been demonstrated after thyroxine treatment in humans with hypothyroidism using the myocardial performance index (MPI). Cardiac changes after thyroxine supplementation are poorly documented in dogs with spontaneous hypothyroidism and comparison...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.15600 |
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| author | Carlo Guglielmini Michele Berlanda Federico Fracassi Helen Poser Shani Koren Marco Baron Toaldo |
| author_facet | Carlo Guglielmini Michele Berlanda Federico Fracassi Helen Poser Shani Koren Marco Baron Toaldo |
| author_sort | Carlo Guglielmini |
| collection | DOAJ |
| description | Abstract Background Improvement in cardiac function has been demonstrated after thyroxine treatment in humans with hypothyroidism using the myocardial performance index (MPI). Cardiac changes after thyroxine supplementation are poorly documented in dogs with spontaneous hypothyroidism and comparison with clinically healthy dogs is lacking. Objectives To evaluate the electrical activity and mechanical function of the heart in dogs with primary hypothyroidism at baseline (T0) and after thyroxine supplementation (T60). Animals Forty client‐owned dogs with hypothyroidism and 20 clinically healthy dogs. Methods Prospective cohort study. Selected electrocardiographic and echocardiographic variables, including the MPI, were measured in all dogs at T0 and in 30 hypothyroid dogs at T60. Results Hypothyroid dogs had significantly decreased median or mean heart rate (HR), P wave amplitude, and R wave amplitude (P = .04, P = .002, and P = .003, respectively) and E‐point‐to‐septal separation normalized to body weight (EPSSn) and trans‐mitral E wave velocity (E max; P < .001 and P = .025, respectively) at T0 compared to control dogs. At T60, significantly increased median or mean HR, P wave amplitude, fractional shortening, and E max (P < .001, P = .004, P = .002, and P = .009, respectively) and significantly decreased left ventricular end‐diastolic volume index, and normalized systolic diameter and EPSSn (P = .03, P = .03, and P = .001, respectively) were found. Conclusions and Clinical Importance Hypothyroidism in dogs induces mild and reversible changes of electromechanical cardiac function. The MPI does not have clinical importance in identifying cardiac dysfunction in affected dogs. |
| first_indexed | 2024-04-12T16:16:17Z |
| format | Article |
| id | doaj.art-473802cd25cd433d8e599aa8e18f0e8a |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-12T16:16:17Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-473802cd25cd433d8e599aa8e18f0e8a2022-12-22T03:25:42ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-09-013351935194210.1111/jvim.15600Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled studyCarlo Guglielmini0Michele Berlanda1Federico Fracassi2Helen Poser3Shani Koren4Marco Baron Toaldo5The Department of Animal Medicine, Production and Health University of Padua Padua ItalyThe Department of Animal Medicine, Production and Health University of Padua Padua ItalyThe Department of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyThe Department of Animal Medicine, Production and Health University of Padua Padua ItalyThe Department of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyThe Department of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyAbstract Background Improvement in cardiac function has been demonstrated after thyroxine treatment in humans with hypothyroidism using the myocardial performance index (MPI). Cardiac changes after thyroxine supplementation are poorly documented in dogs with spontaneous hypothyroidism and comparison with clinically healthy dogs is lacking. Objectives To evaluate the electrical activity and mechanical function of the heart in dogs with primary hypothyroidism at baseline (T0) and after thyroxine supplementation (T60). Animals Forty client‐owned dogs with hypothyroidism and 20 clinically healthy dogs. Methods Prospective cohort study. Selected electrocardiographic and echocardiographic variables, including the MPI, were measured in all dogs at T0 and in 30 hypothyroid dogs at T60. Results Hypothyroid dogs had significantly decreased median or mean heart rate (HR), P wave amplitude, and R wave amplitude (P = .04, P = .002, and P = .003, respectively) and E‐point‐to‐septal separation normalized to body weight (EPSSn) and trans‐mitral E wave velocity (E max; P < .001 and P = .025, respectively) at T0 compared to control dogs. At T60, significantly increased median or mean HR, P wave amplitude, fractional shortening, and E max (P < .001, P = .004, P = .002, and P = .009, respectively) and significantly decreased left ventricular end‐diastolic volume index, and normalized systolic diameter and EPSSn (P = .03, P = .03, and P = .001, respectively) were found. Conclusions and Clinical Importance Hypothyroidism in dogs induces mild and reversible changes of electromechanical cardiac function. The MPI does not have clinical importance in identifying cardiac dysfunction in affected dogs.https://doi.org/10.1111/jvim.15600canineechocardiographyelectrocardiographyendocrine disease |
| spellingShingle | Carlo Guglielmini Michele Berlanda Federico Fracassi Helen Poser Shani Koren Marco Baron Toaldo Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled study Journal of Veterinary Internal Medicine canine echocardiography electrocardiography endocrine disease |
| title | Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled study |
| title_full | Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled study |
| title_fullStr | Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled study |
| title_full_unstemmed | Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled study |
| title_short | Electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation: A prospective controlled study |
| title_sort | electrocardiographic and echocardiographic evaluation in dogs with hypothyroidism before and after levothyroxine supplementation a prospective controlled study |
| topic | canine echocardiography electrocardiography endocrine disease |
| url | https://doi.org/10.1111/jvim.15600 |
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