Metabolic evaluation of high-risk stone formers: a retrospective study
Abstract Background The purpose of this study was to assess the metabolic abnormalities in high-risk stone formers. Methods This was a retrospective observational study done at Tribhuvan University Teaching Hospital, Nepal, over 1-year period. High-risk stone formers were identified and were evaluat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-01-01
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| Series: | African Journal of Urology |
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| Online Access: | https://doi.org/10.1186/s12301-023-00336-8 |
| _version_ | 1828051646498734080 |
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| author | Purushottam Parajuli Bhoj Raj Luitel Manish Man Pradhan Suman Chapagain Sujeet Poudyal Pawan Raj Chalise Uttam Kumar Sharma Prem Raj Gyawali |
| author_facet | Purushottam Parajuli Bhoj Raj Luitel Manish Man Pradhan Suman Chapagain Sujeet Poudyal Pawan Raj Chalise Uttam Kumar Sharma Prem Raj Gyawali |
| author_sort | Purushottam Parajuli |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to assess the metabolic abnormalities in high-risk stone formers. Methods This was a retrospective observational study done at Tribhuvan University Teaching Hospital, Nepal, over 1-year period. High-risk stone formers were identified and were evaluated with serum chemistries and 24-h urinary chemical evaluation. Stone analysis was also included whenever available. Common metabolic abnormalities and stone analysis results were reported and compared with different studies. Continuous variables were expressed as mean ± SD. Categorical variables were expressed as percentage and proportions. Results During 1 year of period, sixty-five patients had undergone extensive metabolic evaluation, but complete data were available for only forty-six patients. Of the total patients (n = 46), 63% were male (n = 29) and rest (36.9%) were female. Mean age of patients was 34.4 ± 15.1 years. Common reasons for metabolic evaluation were multiple stones (40%), bilateral stones (27%), recurrent stones (17%) and others (16%). Most common stone type was mixed stone with predominant composition being calcium oxalate mono- and dihydrate (62.9%). Twenty-four-hour urinary metabolic evaluation showed hyperoxaluria (32.6%) as most common abnormalities followed by hypocitraturia (21.7%) and hypocalciuria (21.7%). Conclusion Hyperoxaluria and hypocitraturia are common metabolic abnormalities in our patients. These findings help in counselling dietary measures to patients. |
| first_indexed | 2024-04-10T19:41:51Z |
| format | Article |
| id | doaj.art-4738101df62242ef9d781e840ab094eb |
| institution | Directory Open Access Journal |
| issn | 1961-9987 |
| language | English |
| last_indexed | 2024-04-10T19:41:51Z |
| publishDate | 2023-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj.art-4738101df62242ef9d781e840ab094eb2023-01-29T12:15:56ZengSpringerOpenAfrican Journal of Urology1961-99872023-01-012911510.1186/s12301-023-00336-8Metabolic evaluation of high-risk stone formers: a retrospective studyPurushottam Parajuli0Bhoj Raj Luitel1Manish Man Pradhan2Suman Chapagain3Sujeet Poudyal4Pawan Raj Chalise5Uttam Kumar Sharma6Prem Raj Gyawali7Department of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineDepartment of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineDepartment of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineDepartment of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineDepartment of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineDepartment of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineDepartment of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineDepartment of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of MedicineAbstract Background The purpose of this study was to assess the metabolic abnormalities in high-risk stone formers. Methods This was a retrospective observational study done at Tribhuvan University Teaching Hospital, Nepal, over 1-year period. High-risk stone formers were identified and were evaluated with serum chemistries and 24-h urinary chemical evaluation. Stone analysis was also included whenever available. Common metabolic abnormalities and stone analysis results were reported and compared with different studies. Continuous variables were expressed as mean ± SD. Categorical variables were expressed as percentage and proportions. Results During 1 year of period, sixty-five patients had undergone extensive metabolic evaluation, but complete data were available for only forty-six patients. Of the total patients (n = 46), 63% were male (n = 29) and rest (36.9%) were female. Mean age of patients was 34.4 ± 15.1 years. Common reasons for metabolic evaluation were multiple stones (40%), bilateral stones (27%), recurrent stones (17%) and others (16%). Most common stone type was mixed stone with predominant composition being calcium oxalate mono- and dihydrate (62.9%). Twenty-four-hour urinary metabolic evaluation showed hyperoxaluria (32.6%) as most common abnormalities followed by hypocitraturia (21.7%) and hypocalciuria (21.7%). Conclusion Hyperoxaluria and hypocitraturia are common metabolic abnormalities in our patients. These findings help in counselling dietary measures to patients.https://doi.org/10.1186/s12301-023-00336-8Renal stoneHigh-risk stone formersMetabolic abnormalitiesMetabolic evaluation |
| spellingShingle | Purushottam Parajuli Bhoj Raj Luitel Manish Man Pradhan Suman Chapagain Sujeet Poudyal Pawan Raj Chalise Uttam Kumar Sharma Prem Raj Gyawali Metabolic evaluation of high-risk stone formers: a retrospective study African Journal of Urology Renal stone High-risk stone formers Metabolic abnormalities Metabolic evaluation |
| title | Metabolic evaluation of high-risk stone formers: a retrospective study |
| title_full | Metabolic evaluation of high-risk stone formers: a retrospective study |
| title_fullStr | Metabolic evaluation of high-risk stone formers: a retrospective study |
| title_full_unstemmed | Metabolic evaluation of high-risk stone formers: a retrospective study |
| title_short | Metabolic evaluation of high-risk stone formers: a retrospective study |
| title_sort | metabolic evaluation of high risk stone formers a retrospective study |
| topic | Renal stone High-risk stone formers Metabolic abnormalities Metabolic evaluation |
| url | https://doi.org/10.1186/s12301-023-00336-8 |
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