UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway

UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway

Abstract Mechanical pressure overload and other stimuli often contribute to heart hypertrophy, a significant factor in the induction of heart failure. The UDP-glucose ceramide glycosyltransferase (UGCG) enzyme plays a crucial role in the metabolism of sphingolipids through the production of glucosyl...

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Bibliographic Details
Main Authors: Shengyu Cui, Xutao Zhang, Yuhua Li, Shan Hu, Bing Wu, Zhao Fang, Jixian Gao, Ming Li, Haoliang Wu, Bo Tao, Hao Xia, Lin Xu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cellular & Molecular Biology Letters
Subjects:
Heart hypertrophy
UGCG
B4GalT5
ERK signaling
Online Access:https://doi.org/10.1186/s11658-023-00484-3

Internet

https://doi.org/10.1186/s11658-023-00484-3

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