Cytokine Signatures for Lung Cancer Diagnosis in African American Populations
Lung cancer is the leading cause of cancer-related deaths among both men and women. African Americans (AAs) experience disproportionately higher incidence and mortality compared to other ethnic groups. Cytokines play multifaceted and crucial roles in the initiation, progression, and spread of cancer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/1/117 |
| _version_ | 1797343193771016192 |
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| author | Qixin Leng Pushpa Dhilipkannah Feng Jiang |
| author_facet | Qixin Leng Pushpa Dhilipkannah Feng Jiang |
| author_sort | Qixin Leng |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer-related deaths among both men and women. African Americans (AAs) experience disproportionately higher incidence and mortality compared to other ethnic groups. Cytokines play multifaceted and crucial roles in the initiation, progression, and spread of cancer. Our aim was to identify cytokine biomarkers for the early detection of lung cancer in AAs. We examined eight key cytokines (Interleukin-1, IL-6, IL-8, IL-10, IL-12p70, monocyte chemotactic protein-1 (MCP-1), interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α)) in the plasma of 104 lung cancer patients and 48 cancer-free individuals using the FirePlex Immunoassay. These findings were subsequently validated in a separate cohort of 58 cases and 58 controls. IL-8, IFN-γ, and TNF-α exhibited elevated levels in both AA and White American (WA) lung cancer cases. Notably, IL-10 and MCP-1 displayed significant increases specifically in AA lung cancer patients, with MCP-1 levels associated with lung adenocarcinoma cases. Conversely, WA lung cancer patients showed heightened IL-6 levels, particularly linked to lung adenocarcinoma. The combined use of specific cytokines showed promise in lung cancer diagnosis, with IL-8, IL-10, and MCP-1 achieving 76% sensitivity and 79% specificity in AAs and IL-6 and IL-8 combined offering 76% sensitivity and 74% specificity in WAs. These diagnostic biomarkers were validated in the independent cohort. The ethnicity-related cytokine biomarkers hold promise for diagnosing lung cancer in AAs and WAs, potentially addressing the observed racial disparity. |
| first_indexed | 2024-03-08T10:44:13Z |
| format | Article |
| id | doaj.art-473ab63be279493eb40cc4d6cabba163 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-08T10:44:13Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-473ab63be279493eb40cc4d6cabba1632024-01-26T17:19:40ZengMDPI AGJournal of Personalized Medicine2075-44262024-01-0114111710.3390/jpm14010117Cytokine Signatures for Lung Cancer Diagnosis in African American PopulationsQixin Leng0Pushpa Dhilipkannah1Feng Jiang2Departments of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartments of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartments of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USALung cancer is the leading cause of cancer-related deaths among both men and women. African Americans (AAs) experience disproportionately higher incidence and mortality compared to other ethnic groups. Cytokines play multifaceted and crucial roles in the initiation, progression, and spread of cancer. Our aim was to identify cytokine biomarkers for the early detection of lung cancer in AAs. We examined eight key cytokines (Interleukin-1, IL-6, IL-8, IL-10, IL-12p70, monocyte chemotactic protein-1 (MCP-1), interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α)) in the plasma of 104 lung cancer patients and 48 cancer-free individuals using the FirePlex Immunoassay. These findings were subsequently validated in a separate cohort of 58 cases and 58 controls. IL-8, IFN-γ, and TNF-α exhibited elevated levels in both AA and White American (WA) lung cancer cases. Notably, IL-10 and MCP-1 displayed significant increases specifically in AA lung cancer patients, with MCP-1 levels associated with lung adenocarcinoma cases. Conversely, WA lung cancer patients showed heightened IL-6 levels, particularly linked to lung adenocarcinoma. The combined use of specific cytokines showed promise in lung cancer diagnosis, with IL-8, IL-10, and MCP-1 achieving 76% sensitivity and 79% specificity in AAs and IL-6 and IL-8 combined offering 76% sensitivity and 74% specificity in WAs. These diagnostic biomarkers were validated in the independent cohort. The ethnicity-related cytokine biomarkers hold promise for diagnosing lung cancer in AAs and WAs, potentially addressing the observed racial disparity.https://www.mdpi.com/2075-4426/14/1/117biomarkerscytokinesplasmalung cancerAfrican Americans |
| spellingShingle | Qixin Leng Pushpa Dhilipkannah Feng Jiang Cytokine Signatures for Lung Cancer Diagnosis in African American Populations Journal of Personalized Medicine biomarkers cytokines plasma lung cancer African Americans |
| title | Cytokine Signatures for Lung Cancer Diagnosis in African American Populations |
| title_full | Cytokine Signatures for Lung Cancer Diagnosis in African American Populations |
| title_fullStr | Cytokine Signatures for Lung Cancer Diagnosis in African American Populations |
| title_full_unstemmed | Cytokine Signatures for Lung Cancer Diagnosis in African American Populations |
| title_short | Cytokine Signatures for Lung Cancer Diagnosis in African American Populations |
| title_sort | cytokine signatures for lung cancer diagnosis in african american populations |
| topic | biomarkers cytokines plasma lung cancer African Americans |
| url | https://www.mdpi.com/2075-4426/14/1/117 |
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