Experience of clinical management of mixed urogenital tract infections in women
<div> <b>Experience of clinical management of mixed urogenital tract infections in women</b> </div> <div> <b><br> </b> </div> I.O. Borovikov, I.I. Kutsenko, E.R. Rubinina<br> Kuban state medical university, Krasnodar, Russian Federatio...
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| Format: | Article |
| Language: | Russian |
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LCC «Medicine-Inform»
2018-09-01
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| Series: | РМЖ. Мать и дитя |
| Online Access: | http://wchjournal.com/upload/iblock/f43/f436ab09e9cfd2da41b5bba3c61cc946.pdf |
| _version_ | 1797294962428084224 |
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| author | Borovikov I.O. Kutsenko I.I. E.R. Rubinina |
| author_facet | Borovikov I.O. Kutsenko I.I. E.R. Rubinina |
| author_sort | Borovikov I.O. |
| collection | DOAJ |
| description | <div>
<b>Experience of clinical management of mixed urogenital tract infections in women</b>
</div>
<div>
<b><br>
</b>
</div>
I.O. Borovikov, I.I. Kutsenko, E.R. Rubinina<br>
Kuban state medical university, Krasnodar, Russian Federation<br>
<br>
<p>
<i>The article considers experience of managing the patients with various infections of the urogenital tract (bacterial vaginosis in combination with urogenital candidiasis and chlamydia infection, bacterial vaginosis during pregnancy). The clinical features of combined forms of urogenital infection in women are presented and variants of treatment of this pathology are offered with an assessment of their clinical and microbiological efficacy.</i>
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<i>Aim: assessment of clinical experience of various options for the management of women with urogenital infections.</i>
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<i>Patients and Methods: the article presents the analysis of the therapy of 63 patients with a mixed form of urogenital infection (a combination of bacterial vaginosis and vulvovaginal candidosis — n=32 and bacterial vaginosis with chlamydial infection — n=31), and 28 pregnant women in gestation period 28-36 weeks with diagnosed bacterial vaginosis. An assessment of the state of microbiota in the urogenital tract was carried out using a polymerase chain reaction (PCR) in real time. Diagnosis of Chlamydia infection was carried out by PCR. Diagnosis of infection with various species of Candida spp.: direct microscopy, seeding with pure culture separation and the final identification of the pathogen. Quantitative assessment of urogenital biota was carried out in absolute and relative values. Treatment of bacterial vaginosis in combination with vulvovaginal vandidiasis was conducted locally clindamycin phosphate and systemic fluconazole, with the combination of bacterial vaginosis and chlamydia infection used clindamycin with azithromycin, in pregnant women in the II-III trimester treatment of bacterial vaginosis was clindamycin in combination with natamycin.</i>
</p>
<p>
<i>Results: clinical cure of patients with bacterial vaginosis in combination with candidiasis with complex therapy with clindamycin combined with fluconazole was 87.5±4.6%, microbiological — 82.3±6.1%. For patients with bacterial vaginosis in combination with chlamydial infection and clindamycin phosphate therapy in combination with azithromycin, the clinical efficacy was 82.8±8.2%, the microbiological efficacy was 79.6±5.9%. The microbiological efficacy of treatment of bacterial vaginosis with clindamycin phosphate in the II–III trimesters of pregnancy was 86.3%.</i>
</p>
<p>
<i>Conclusions: high efficacy of local therapy of bacterial vaginosis with antibacterial drug clindamycin phosphate (which can also be used in the II and III trimester of pregnancy) is revealed, the systemic antifungal drug fluconazole does not lose its relevance and efficacy as antimycotic therapy.</i>
</p>
<p>
<i>Key words: bacterial vaginosis, vulvovaginal candidiasis, chlamydia infection, antimycotics, fluconazole, clindamycin phosphate.</i>
</p>
<p>
<i>For citation: Borovikov I.O., Kutsenko I.I., Rubinina E.R. Experience of clinical management of mixed urogenital tract infections in women. Russian journal of Woman and Child Health. 2018;1(1):26–32.</i>
</p> |
| first_indexed | 2024-03-07T21:39:22Z |
| format | Article |
| id | doaj.art-473bae0f939641ec94f7c0394e216784 |
| institution | Directory Open Access Journal |
| issn | 2618-8430 2686-7184 |
| language | Russian |
| last_indexed | 2024-03-07T21:39:22Z |
| publishDate | 2018-09-01 |
| publisher | LCC «Medicine-Inform» |
| record_format | Article |
| series | РМЖ. Мать и дитя |
| spelling | doaj.art-473bae0f939641ec94f7c0394e2167842024-02-26T10:13:31ZrusLCC «Medicine-Inform»РМЖ. Мать и дитя2618-84302686-71842018-09-011132172Experience of clinical management of mixed urogenital tract infections in womenBorovikov I.O.0Kutsenko I.I.1E.R. Rubinina2Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<div> <b>Experience of clinical management of mixed urogenital tract infections in women</b> </div> <div> <b><br> </b> </div> I.O. Borovikov, I.I. Kutsenko, E.R. Rubinina<br> Kuban state medical university, Krasnodar, Russian Federation<br> <br> <p> <i>The article considers experience of managing the patients with various infections of the urogenital tract (bacterial vaginosis in combination with urogenital candidiasis and chlamydia infection, bacterial vaginosis during pregnancy). The clinical features of combined forms of urogenital infection in women are presented and variants of treatment of this pathology are offered with an assessment of their clinical and microbiological efficacy.</i> </p> <p> <i>Aim: assessment of clinical experience of various options for the management of women with urogenital infections.</i> </p> <p> <i>Patients and Methods: the article presents the analysis of the therapy of 63 patients with a mixed form of urogenital infection (a combination of bacterial vaginosis and vulvovaginal candidosis — n=32 and bacterial vaginosis with chlamydial infection — n=31), and 28 pregnant women in gestation period 28-36 weeks with diagnosed bacterial vaginosis. An assessment of the state of microbiota in the urogenital tract was carried out using a polymerase chain reaction (PCR) in real time. Diagnosis of Chlamydia infection was carried out by PCR. Diagnosis of infection with various species of Candida spp.: direct microscopy, seeding with pure culture separation and the final identification of the pathogen. Quantitative assessment of urogenital biota was carried out in absolute and relative values. Treatment of bacterial vaginosis in combination with vulvovaginal vandidiasis was conducted locally clindamycin phosphate and systemic fluconazole, with the combination of bacterial vaginosis and chlamydia infection used clindamycin with azithromycin, in pregnant women in the II-III trimester treatment of bacterial vaginosis was clindamycin in combination with natamycin.</i> </p> <p> <i>Results: clinical cure of patients with bacterial vaginosis in combination with candidiasis with complex therapy with clindamycin combined with fluconazole was 87.5±4.6%, microbiological — 82.3±6.1%. For patients with bacterial vaginosis in combination with chlamydial infection and clindamycin phosphate therapy in combination with azithromycin, the clinical efficacy was 82.8±8.2%, the microbiological efficacy was 79.6±5.9%. The microbiological efficacy of treatment of bacterial vaginosis with clindamycin phosphate in the II–III trimesters of pregnancy was 86.3%.</i> </p> <p> <i>Conclusions: high efficacy of local therapy of bacterial vaginosis with antibacterial drug clindamycin phosphate (which can also be used in the II and III trimester of pregnancy) is revealed, the systemic antifungal drug fluconazole does not lose its relevance and efficacy as antimycotic therapy.</i> </p> <p> <i>Key words: bacterial vaginosis, vulvovaginal candidiasis, chlamydia infection, antimycotics, fluconazole, clindamycin phosphate.</i> </p> <p> <i>For citation: Borovikov I.O., Kutsenko I.I., Rubinina E.R. Experience of clinical management of mixed urogenital tract infections in women. Russian journal of Woman and Child Health. 2018;1(1):26–32.</i> </p>http://wchjournal.com/upload/iblock/f43/f436ab09e9cfd2da41b5bba3c61cc946.pdf |
| spellingShingle | Borovikov I.O. Kutsenko I.I. E.R. Rubinina Experience of clinical management of mixed urogenital tract infections in women РМЖ. Мать и дитя |
| title | Experience of clinical management of mixed urogenital tract infections in women |
| title_full | Experience of clinical management of mixed urogenital tract infections in women |
| title_fullStr | Experience of clinical management of mixed urogenital tract infections in women |
| title_full_unstemmed | Experience of clinical management of mixed urogenital tract infections in women |
| title_short | Experience of clinical management of mixed urogenital tract infections in women |
| title_sort | experience of clinical management of mixed urogenital tract infections in women |
| url | http://wchjournal.com/upload/iblock/f43/f436ab09e9cfd2da41b5bba3c61cc946.pdf |
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