A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy
The main objective of this systematic review is to investigate the expression level of the cyclooxygenase-2 (COX-2) in rectal cancer treated with either preoperative radiotherapy or radiochemotherapy. In addition, we have summarized the effects of preoperative treatment of rectal cancer with regards...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/19/4443 |
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| author | Monika Berbecka Alicja Forma Jacek Baj Marzena Furtak-Niczyporuk Ryszard Maciejewski Robert Sitarz |
| author_facet | Monika Berbecka Alicja Forma Jacek Baj Marzena Furtak-Niczyporuk Ryszard Maciejewski Robert Sitarz |
| author_sort | Monika Berbecka |
| collection | DOAJ |
| description | The main objective of this systematic review is to investigate the expression level of the cyclooxygenase-2 (COX-2) in rectal cancer treated with either preoperative radiotherapy or radiochemotherapy. In addition, we have summarized the effects of preoperative treatment of rectal cancer with regards to the expression levels of COX-2. A systematic literature review was performed in The Cochrane Library, PubMed, Web of Science, and Scopus databases on 1 January 2021 with the usage of the following search string—(cyclooxygenase-2) OR (COX-2) AND (rectal cancer) AND (preoperative radiochemotherapy) OR (preoperative radiotherapy). Among the 176 included in the analysis, only 13 studies were included for data extraction with a total number of 2095 patients. The results of the analysis are based on the articles concerning the expression of COX-2 in rectal cancer among patients treated with preoperative radiotherapy or radiochemotherapy. A COX-2 expression is an early event involved in rectal cancer development. In cases of negative COX-2 expression, radiotherapy and radiochemotherapy might contribute to the reduction of a local recurrence. Therefore, COX-2 may be considered as a biologic factor while selecting patients for more effective, less time-consuming and less expensive preoperative treatment. However, the utility of the administration of COX-2 inhibitors to patients with COX-2 overexpression, in an attempt to improve the patients’ response rate to the neoadjuvant treatment, needs an assessment in further clinical trials. |
| first_indexed | 2024-03-10T06:57:49Z |
| format | Article |
| id | doaj.art-473c227dc5ab4e1c9db7a871eaf06d06 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T06:57:49Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-473c227dc5ab4e1c9db7a871eaf06d062023-11-22T16:19:32ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011019444310.3390/jcm10194443A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or RadiochemotherapyMonika Berbecka0Alicja Forma1Jacek Baj2Marzena Furtak-Niczyporuk3Ryszard Maciejewski4Robert Sitarz5Department of Normal Anatomy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Normal Anatomy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Public Health, Medical University of Lublin, 20-954 Lublin, PolandDepartment of Normal Anatomy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Normal Anatomy, Medical University of Lublin, 20-090 Lublin, PolandThe main objective of this systematic review is to investigate the expression level of the cyclooxygenase-2 (COX-2) in rectal cancer treated with either preoperative radiotherapy or radiochemotherapy. In addition, we have summarized the effects of preoperative treatment of rectal cancer with regards to the expression levels of COX-2. A systematic literature review was performed in The Cochrane Library, PubMed, Web of Science, and Scopus databases on 1 January 2021 with the usage of the following search string—(cyclooxygenase-2) OR (COX-2) AND (rectal cancer) AND (preoperative radiochemotherapy) OR (preoperative radiotherapy). Among the 176 included in the analysis, only 13 studies were included for data extraction with a total number of 2095 patients. The results of the analysis are based on the articles concerning the expression of COX-2 in rectal cancer among patients treated with preoperative radiotherapy or radiochemotherapy. A COX-2 expression is an early event involved in rectal cancer development. In cases of negative COX-2 expression, radiotherapy and radiochemotherapy might contribute to the reduction of a local recurrence. Therefore, COX-2 may be considered as a biologic factor while selecting patients for more effective, less time-consuming and less expensive preoperative treatment. However, the utility of the administration of COX-2 inhibitors to patients with COX-2 overexpression, in an attempt to improve the patients’ response rate to the neoadjuvant treatment, needs an assessment in further clinical trials.https://www.mdpi.com/2077-0383/10/19/4443rectal adenocarcinomarectal cancercyclooxygenase-2COX-2radiotherapychemoradiotherapy |
| spellingShingle | Monika Berbecka Alicja Forma Jacek Baj Marzena Furtak-Niczyporuk Ryszard Maciejewski Robert Sitarz A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy Journal of Clinical Medicine rectal adenocarcinoma rectal cancer cyclooxygenase-2 COX-2 radiotherapy chemoradiotherapy |
| title | A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy |
| title_full | A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy |
| title_fullStr | A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy |
| title_full_unstemmed | A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy |
| title_short | A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy |
| title_sort | systematic review of the cyclooxygenase 2 cox 2 expression in rectal cancer patients treated with preoperative radiotherapy or radiochemotherapy |
| topic | rectal adenocarcinoma rectal cancer cyclooxygenase-2 COX-2 radiotherapy chemoradiotherapy |
| url | https://www.mdpi.com/2077-0383/10/19/4443 |
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