Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats
The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived co...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-07-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2020.1762894 |
| _version_ | 1827814493783064576 |
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| author | Irina Rozkova Eugeny Brusentsev Tatyana Igonina Diana Ragaeva Olga Petrova Maria A. Tikhonova Anna A. Akopyan Tamara G. Amstislavskaya Yegor V. Antonov Sergey Amstislavsky |
| author_facet | Irina Rozkova Eugeny Brusentsev Tatyana Igonina Diana Ragaeva Olga Petrova Maria A. Tikhonova Anna A. Akopyan Tamara G. Amstislavskaya Yegor V. Antonov Sergey Amstislavsky |
| author_sort | Irina Rozkova |
| collection | DOAJ |
| description | The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal BDNF expression, and compensatory increasing of hippocampal neuronal density in adult ISIAH offspring. Maternal surgery during early pregnancy caused alterations in offspring phenotype in hypertensive ISIAH rat model. |
| first_indexed | 2024-03-11T23:46:55Z |
| format | Article |
| id | doaj.art-473d5635dd784eb2ae4e9240b7756151 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:55Z |
| publishDate | 2020-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-473d5635dd784eb2ae4e9240b77561512023-09-19T09:24:43ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652020-07-0139328329410.1080/10641955.2020.17628941762894Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH ratsIrina Rozkova0Eugeny Brusentsev1Tatyana Igonina2Diana Ragaeva3Olga Petrova4Maria A. Tikhonova5Anna A. Akopyan6Tamara G. Amstislavskaya7Yegor V. Antonov8Sergey Amstislavsky9Federal State Budgetary Scientific Institution “Federal Research Center Institute of Cytology and Genetics”Federal State Budgetary Scientific Institution “Federal Research Center Institute of Cytology and Genetics”Federal State Budgetary Scientific Institution “Federal Research Center Institute of Cytology and Genetics”Federal State Budgetary Scientific Institution “Federal Research Center Institute of Cytology and Genetics”Federal State Budgetary Scientific Institution “Federal Research Center Institute of Cytology and Genetics”Federal State Budgetary Scientific Institution “Scientific Research Institute of Physiology and Basic Medicine”Federal State Budgetary Scientific Institution “Scientific Research Institute of Physiology and Basic Medicine”Federal State Budgetary Scientific Institution “Scientific Research Institute of Physiology and Basic Medicine”Federal State Budgetary Scientific Institution “Federal Research Center Institute of Cytology and Genetics”Federal State Budgetary Scientific Institution “Federal Research Center Institute of Cytology and Genetics”The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal BDNF expression, and compensatory increasing of hippocampal neuronal density in adult ISIAH offspring. Maternal surgery during early pregnancy caused alterations in offspring phenotype in hypertensive ISIAH rat model.http://dx.doi.org/10.1080/10641955.2020.1762894hypertensionpregnancyoffspring neurodevelopmentblood pressurebrain |
| spellingShingle | Irina Rozkova Eugeny Brusentsev Tatyana Igonina Diana Ragaeva Olga Petrova Maria A. Tikhonova Anna A. Akopyan Tamara G. Amstislavskaya Yegor V. Antonov Sergey Amstislavsky Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats Hypertension in Pregnancy hypertension pregnancy offspring neurodevelopment blood pressure brain |
| title | Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats |
| title_full | Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats |
| title_fullStr | Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats |
| title_full_unstemmed | Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats |
| title_short | Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats |
| title_sort | sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in isiah rats |
| topic | hypertension pregnancy offspring neurodevelopment blood pressure brain |
| url | http://dx.doi.org/10.1080/10641955.2020.1762894 |
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