UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling Materials
High-performance properties of interpenetration polymer network (IPN) hydrogels, based on physically crosslinked chitosan (CS) and chemically crosslinked poly(<i>N</i>-isopropylacrylamide) (PNiPAM), were successfully developed. The IPN of CS/PNiPAM is proposed to overcome the limited mec...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/1/20 |
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| author | Isala Dueramae Fumihiko Tanaka Naoki Shinyashiki Shin Yagihara Rio Kita |
| author_facet | Isala Dueramae Fumihiko Tanaka Naoki Shinyashiki Shin Yagihara Rio Kita |
| author_sort | Isala Dueramae |
| collection | DOAJ |
| description | High-performance properties of interpenetration polymer network (IPN) hydrogels, based on physically crosslinked chitosan (CS) and chemically crosslinked poly(<i>N</i>-isopropylacrylamide) (PNiPAM), were successfully developed. The IPN of CS/PNiPAM is proposed to overcome the limited mechanical properties of the single CS network. In this study, the viscoelastic behaviors of prepared materials in both solution and gel states were extensively examined, considering the UV exposure time and crosslinker concentration as key factors. The effect of these factors on gel formation, hydrogel structures, thermal stabilities of networks, and HeLa cell adhesion were studied sequentially. The sol–gel transition was effectively demonstrated through the scaling law, which agrees well with Winter and Chambon’s theory. By subjecting the CS hydrogel to the process operation in an ethanol solution, its properties can be significantly enhanced with increased crosslinker concentration, including the shear modulus, crosslinking degree, gel strength, and thermal stability in its swollen state. The IPN samples exhibit a smooth and dense surface with irregular pores, allowing for much water absorption. The HeLa cells were adhered to and killed using the CS surface cationic charges and then released through hydrolysis by utilizing the hydrophilic/hydrophobic switchable property or thermo-reversible gelation of the PNiPAM network. The results demonstrated that IPN is a highly attractive candidate for anti-fouling materials. |
| first_indexed | 2024-03-08T10:54:09Z |
| format | Article |
| id | doaj.art-473dd59ff7b0484e9b75964f08152e2b |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-08T10:54:09Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-473dd59ff7b0484e9b75964f08152e2b2024-01-26T16:39:02ZengMDPI AGGels2310-28612023-12-011012010.3390/gels10010020UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling MaterialsIsala Dueramae0Fumihiko Tanaka1Naoki Shinyashiki2Shin Yagihara3Rio Kita4Micro/Nano Technology Center, Tokai University, Hiratsuka 259-1292, JapanDepartment of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, JapanMicro/Nano Technology Center, Tokai University, Hiratsuka 259-1292, JapanDepartment of Physics, Tokai University, Hiratsuka 259-1292, JapanMicro/Nano Technology Center, Tokai University, Hiratsuka 259-1292, JapanHigh-performance properties of interpenetration polymer network (IPN) hydrogels, based on physically crosslinked chitosan (CS) and chemically crosslinked poly(<i>N</i>-isopropylacrylamide) (PNiPAM), were successfully developed. The IPN of CS/PNiPAM is proposed to overcome the limited mechanical properties of the single CS network. In this study, the viscoelastic behaviors of prepared materials in both solution and gel states were extensively examined, considering the UV exposure time and crosslinker concentration as key factors. The effect of these factors on gel formation, hydrogel structures, thermal stabilities of networks, and HeLa cell adhesion were studied sequentially. The sol–gel transition was effectively demonstrated through the scaling law, which agrees well with Winter and Chambon’s theory. By subjecting the CS hydrogel to the process operation in an ethanol solution, its properties can be significantly enhanced with increased crosslinker concentration, including the shear modulus, crosslinking degree, gel strength, and thermal stability in its swollen state. The IPN samples exhibit a smooth and dense surface with irregular pores, allowing for much water absorption. The HeLa cells were adhered to and killed using the CS surface cationic charges and then released through hydrolysis by utilizing the hydrophilic/hydrophobic switchable property or thermo-reversible gelation of the PNiPAM network. The results demonstrated that IPN is a highly attractive candidate for anti-fouling materials.https://www.mdpi.com/2310-2861/10/1/20chitosanpoly(<i>N</i>-isopropylacrylamide)thermo-reversible gelationinterpenetration polymer networkviscoelastic propertyanti-fouling materials |
| spellingShingle | Isala Dueramae Fumihiko Tanaka Naoki Shinyashiki Shin Yagihara Rio Kita UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling Materials Gels chitosan poly(<i>N</i>-isopropylacrylamide) thermo-reversible gelation interpenetration polymer network viscoelastic property anti-fouling materials |
| title | UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling Materials |
| title_full | UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling Materials |
| title_fullStr | UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling Materials |
| title_full_unstemmed | UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling Materials |
| title_short | UV-Crosslinked Poly(<i>N</i>-isopropylacrylamide) Interpenetrated into Chitosan Structure with Enhancement of Mechanical Properties Implemented as Anti-Fouling Materials |
| title_sort | uv crosslinked poly i n i isopropylacrylamide interpenetrated into chitosan structure with enhancement of mechanical properties implemented as anti fouling materials |
| topic | chitosan poly(<i>N</i>-isopropylacrylamide) thermo-reversible gelation interpenetration polymer network viscoelastic property anti-fouling materials |
| url | https://www.mdpi.com/2310-2861/10/1/20 |
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