Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease
Few studies have investigated differences in functional connectivity (FC) between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer’s disease (AD), especially in relation to apathy. Therefore, the aim of this study was to compare apathy-related FC changes among patients with S...
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.717037/full |
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| author | Sabri Altunkaya Sheng-Min Huang Yen-Hsuan Hsu Yen-Hsuan Hsu Jir-Jei Yang Chien-Yuan Lin Li-Wei Kuo Li-Wei Kuo Min-Chien Tu Min-Chien Tu |
| author_facet | Sabri Altunkaya Sheng-Min Huang Yen-Hsuan Hsu Yen-Hsuan Hsu Jir-Jei Yang Chien-Yuan Lin Li-Wei Kuo Li-Wei Kuo Min-Chien Tu Min-Chien Tu |
| author_sort | Sabri Altunkaya |
| collection | DOAJ |
| description | Few studies have investigated differences in functional connectivity (FC) between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer’s disease (AD), especially in relation to apathy. Therefore, the aim of this study was to compare apathy-related FC changes among patients with SIVD, AD, and cognitively normal subjects. The SIVD group had the highest level of apathy as measured using the Apathy Evaluation Scale-clinician version (AES). Dementia staging, volume of white matter hyperintensities (WMH), and the Beck Depression Inventory were the most significant clinical predictors for apathy. Group-wise comparisons revealed that the SIVD patients had the worst level of “Initiation” by factor analysis of the AES. FCs from four resting state networks (RSNs) were compared, and the connectograms at the level of intra- and inter-RSNs revealed dissociable FC changes, shared FC in the dorsal attention network, and distinct FC in the salient network across SIVD and AD. Neuronal correlates for “Initiation” deficits that underlie apathy were explored through a regional-specific approach, which showed that the right inferior frontal gyrus, left middle frontal gyrus, and left anterior insula were the critical hubs. These findings broaden the disconnection theory by considering the effect of FC interactions across multiple RSNs on apathy formation. |
| first_indexed | 2024-04-11T19:34:57Z |
| format | Article |
| id | doaj.art-473fd85b399f48e2a39f2a2ed95381dc |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T19:34:57Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-473fd85b399f48e2a39f2a2ed95381dc2022-12-22T04:06:52ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-02-011310.3389/fnagi.2021.717037717037Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s DiseaseSabri Altunkaya0Sheng-Min Huang1Yen-Hsuan Hsu2Yen-Hsuan Hsu3Jir-Jei Yang4Chien-Yuan Lin5Li-Wei Kuo6Li-Wei Kuo7Min-Chien Tu8Min-Chien Tu9Department of Electrical and Electronics Engineering, Necmettin Erbakan University, Konya, TurkeyInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, TaiwanDepartment of Psychology, National Chung Cheng University, Chiayi, TaiwanCenter for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Chaiyi, TaiwanDepartment of Radiology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, TaiwanGE Healthcare, GE Medical Systems Taiwan, Ltd., Taipei, TaiwanInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, TaiwanInstitute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Neurology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, TaiwanDepartment of Neurology, School of Medicine, Tzu Chi University, Hualien, TaiwanFew studies have investigated differences in functional connectivity (FC) between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer’s disease (AD), especially in relation to apathy. Therefore, the aim of this study was to compare apathy-related FC changes among patients with SIVD, AD, and cognitively normal subjects. The SIVD group had the highest level of apathy as measured using the Apathy Evaluation Scale-clinician version (AES). Dementia staging, volume of white matter hyperintensities (WMH), and the Beck Depression Inventory were the most significant clinical predictors for apathy. Group-wise comparisons revealed that the SIVD patients had the worst level of “Initiation” by factor analysis of the AES. FCs from four resting state networks (RSNs) were compared, and the connectograms at the level of intra- and inter-RSNs revealed dissociable FC changes, shared FC in the dorsal attention network, and distinct FC in the salient network across SIVD and AD. Neuronal correlates for “Initiation” deficits that underlie apathy were explored through a regional-specific approach, which showed that the right inferior frontal gyrus, left middle frontal gyrus, and left anterior insula were the critical hubs. These findings broaden the disconnection theory by considering the effect of FC interactions across multiple RSNs on apathy formation.https://www.frontiersin.org/articles/10.3389/fnagi.2021.717037/fullfunctional magnetic resonance imagingresting-state functional connectivitydisconnection syndromeapathysubcortical ischemic vascular diseaseAlzheirmer’s disease |
| spellingShingle | Sabri Altunkaya Sheng-Min Huang Yen-Hsuan Hsu Yen-Hsuan Hsu Jir-Jei Yang Chien-Yuan Lin Li-Wei Kuo Li-Wei Kuo Min-Chien Tu Min-Chien Tu Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease Frontiers in Aging Neuroscience functional magnetic resonance imaging resting-state functional connectivity disconnection syndrome apathy subcortical ischemic vascular disease Alzheirmer’s disease |
| title | Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease |
| title_full | Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease |
| title_fullStr | Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease |
| title_full_unstemmed | Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease |
| title_short | Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease |
| title_sort | dissociable functional brain networks associated with apathy in subcortical ischemic vascular disease and alzheimer s disease |
| topic | functional magnetic resonance imaging resting-state functional connectivity disconnection syndrome apathy subcortical ischemic vascular disease Alzheirmer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.717037/full |
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