Oncofertility in men cured of Hodgkin’s lymphoma as a child
Hodgkin’s lymphoma, being a highly malignant disease, has now acquired the property of a curative one. The article describes the basic principles of therapy of children with Hodgkin’s lymphoma, slow fixation of risk-adapted treatment positions. The possibility of complete cure of most patients appea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2019-06-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/3068 |
| _version_ | 1827962411667161088 |
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| author | S. A. Kuleva D. N. Kurochkina D. A. Zvyagintseva S. V. Ivanova Ye. V. Tsyrlina |
| author_facet | S. A. Kuleva D. N. Kurochkina D. A. Zvyagintseva S. V. Ivanova Ye. V. Tsyrlina |
| author_sort | S. A. Kuleva |
| collection | DOAJ |
| description | Hodgkin’s lymphoma, being a highly malignant disease, has now acquired the property of a curative one. The article describes the basic principles of therapy of children with Hodgkin’s lymphoma, slow fixation of risk-adapted treatment positions. The possibility of complete cure of most patients appeared, which made this tumor a unique model for studying the remote consequences of cancer treatment. After the antitumor treatment of Hodgkin’s lymphoma, boys may suffer from testicular insufficiency (due to cytostatics), obstructive azoospermia (as a consequence of radiation therapy in the pelvic area), hypogonadism (secondary - after exposure of the pituitary gland to radiation, primary - after exposure of the pelvis due to the toxic effects of cytostatics). In order to reduce the gonadotoxicity of treatment, studies are being conducted to modify chemotherapy in the direction of lowering the doses of alkylating cytostatics, reducing the doses of radiation therapy without losing the effectiveness of treatment. Regardless of the cause of male infertility diagnosis includes the collection of reproductive history, external examination of the genitals, analysis of ejaculate, ultrasound examination of the scrotum, assessment of hormone levels (follicle stimulating hormone, total testosterone, serum testosterone, luteinizing hormone, prolactin, inhibin B, thyroid stimulating hormone). |
| first_indexed | 2024-04-09T16:42:13Z |
| format | Article |
| id | doaj.art-4740528915314cf6b28086402797ed97 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:42:13Z |
| publishDate | 2019-06-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-4740528915314cf6b28086402797ed972023-04-23T06:56:38ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902019-06-0101016417110.21518/2079-701X-2019-10-164-1712982Oncofertility in men cured of Hodgkin’s lymphoma as a childS. A. Kuleva0D. N. Kurochkina1D. A. Zvyagintseva2S. V. Ivanova3Ye. V. Tsyrlina4Federal State Budgetary Institution «National Medical Research Center of Oncology named after N.N. Petrov» of the Ministry of Health of the Russian Federation.State budgetary institution of public health «Saint-Petersburg Clinical Scientific and Practical Center of Specialized Medical Care (Oncological)».Federal State Budgetary Institution «National Medical Research Center of Oncology named after N.N. Petrov» of the Ministry of Health of the Russian Federation.Federal State Budgetary Institution «National Medical Research Center of Oncology named after N.N. Petrov» of the Ministry of Health of the Russian Federation.Federal State Budgetary Institution «National Medical Research Center of Oncology named after N.N. Petrov» of the Ministry of Health of the Russian Federation.Hodgkin’s lymphoma, being a highly malignant disease, has now acquired the property of a curative one. The article describes the basic principles of therapy of children with Hodgkin’s lymphoma, slow fixation of risk-adapted treatment positions. The possibility of complete cure of most patients appeared, which made this tumor a unique model for studying the remote consequences of cancer treatment. After the antitumor treatment of Hodgkin’s lymphoma, boys may suffer from testicular insufficiency (due to cytostatics), obstructive azoospermia (as a consequence of radiation therapy in the pelvic area), hypogonadism (secondary - after exposure of the pituitary gland to radiation, primary - after exposure of the pelvis due to the toxic effects of cytostatics). In order to reduce the gonadotoxicity of treatment, studies are being conducted to modify chemotherapy in the direction of lowering the doses of alkylating cytostatics, reducing the doses of radiation therapy without losing the effectiveness of treatment. Regardless of the cause of male infertility diagnosis includes the collection of reproductive history, external examination of the genitals, analysis of ejaculate, ultrasound examination of the scrotum, assessment of hormone levels (follicle stimulating hormone, total testosterone, serum testosterone, luteinizing hormone, prolactin, inhibin B, thyroid stimulating hormone).https://www.med-sovet.pro/jour/article/view/3068boyshodgkin’s lymphomagonadotoxicityfertilityalkylating drugsradiation therapy |
| spellingShingle | S. A. Kuleva D. N. Kurochkina D. A. Zvyagintseva S. V. Ivanova Ye. V. Tsyrlina Oncofertility in men cured of Hodgkin’s lymphoma as a child Медицинский совет boys hodgkin’s lymphoma gonadotoxicity fertility alkylating drugs radiation therapy |
| title | Oncofertility in men cured of Hodgkin’s lymphoma as a child |
| title_full | Oncofertility in men cured of Hodgkin’s lymphoma as a child |
| title_fullStr | Oncofertility in men cured of Hodgkin’s lymphoma as a child |
| title_full_unstemmed | Oncofertility in men cured of Hodgkin’s lymphoma as a child |
| title_short | Oncofertility in men cured of Hodgkin’s lymphoma as a child |
| title_sort | oncofertility in men cured of hodgkin s lymphoma as a child |
| topic | boys hodgkin’s lymphoma gonadotoxicity fertility alkylating drugs radiation therapy |
| url | https://www.med-sovet.pro/jour/article/view/3068 |
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