Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism

Cardiac fibrosis represents a serious clinical problem. Development of novel treatment strategies is currently restricted by the lack of the relevant experimental models in a human genetic context. In this study, we fabricated self-aggregating, scaffold-free, 3D cardiac microtissues using human indu...

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Bibliographic Details
Main Authors: Przemysław Błyszczuk, Christian Zuppinger, Ana Costa, Daria Nurzynska, Franca Di Meglio, Mara Stellato, Irina Agarkova, Godfrey L. Smith, Oliver Distler, Gabriela Kania
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
cardiac microtissues
iPSC-derived cardiomyocytes
cardiac fibroblasts
cardiac fibrosis
cardiac rhythm
TGF-β signalling
Online Access:https://www.mdpi.com/2073-4409/9/5/1270

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